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Publications

  1. Rameh, LE and Blind, RD. 25 years of PI-5-P. Front. Cell Dev. Biol. 2023;11:1272911. doi: 10.3389/fcell.2023.1272911.
  2. Sowd, GA; Stivison, EA; Chapagain, P; Hale, A; Poland, JC; Rameh, LE; Blind, RD. IPMK regulates HDAC3 and histone H4acetylation in human cells. ELife. 2023, under review.
  3. Wohlrab, H; Signoretti, S; Rameh, LE; DeConti, D; Hansen, S. Mitochondrial transporter expression patterns distinguish tumor from normal tissue and identify cancer subtypes with different survival and metabolism. Sci Rep. 2022; 12(1):17035. doi: 10.1038/s41598-022-21411-0.
  4. Rumala, CZ; Liu, J.; Locasale, JW; Corkey, BE; Deeney, JT; Rameh, LE. Exposure of pancreatic ß-cells to excess glucose results in bimodal activation of mTORC1 and mTOR-dependent metabolic acceleration. iScience. 2020; 23 (2), 100858.
  5. Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK. Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Oncotarget. 2017; 8 (27): 43733-51. PubMed PMID: 28415827.
  6. Rameh LE, Mackey AM. IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3. Nature Cell Biology. 2016;18(12):1263-5. doi: 10.1038/ncb3440. PubMed PMID: 27897158.
  7. Rameh LE, Deeney JT. Phosphoinositide Signaling in Type 2 Diabetes: a ß-Cell Perspective. Biochem. Soc. Trans. 2016; 44: 293-8. PMID: 26862218.
  8. Sarkes D, Rameh LE.. Analysis of the phosphoinositide composition of subcellular membrane fractions. In Methods Mol Biol. 2016;1376:213-27. PubMed PMID: 26552687.
  9. Toker, A & Rameh L. PIPPing on AKT: How many phosphatases does it take to turn off PI3K? Cancer Cell. 2015; 28: 143-5.
  10. Mackey AM, Sarkes D, Bettencourt I, Asara JM and Rameh LE. PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation. Science Signaling. 2014; 7 (350).
  11. Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J. AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Science Signaling. 2013;6(279):ra45. Epub 2013/06/13. doi: 10.1126/scisignal.2004015. PubMed PMID: 23757022.
  12. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013;155(4):844-57. Epub 2013/11/12. doi: 10.1016/j.cell.2013.09.057. PubMed PMID: 24209622.
  13. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Nagle A, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TR, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013;504(7479):248-53. Epub 2013/11/29. doi: 10.1038/nature12782. PubMed PMID: 24284631.
  14. Wesche J, Oppelt A, Lobert V, Haglund K, Mackey A, Rameh L, Liestøl K, Pedersen NM, Brech A, Rusten TE, Stenmark H, Schink K, Wenzel E and Haugsten E. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep. 2012; 14(1): 57-64. PMID: 23154468.
  15. Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell 2012; 149(1):49-62. PMID: 22401813.
  16. Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, Boes M, Regueiro JR, Reinecker HC, Terhorst C. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat. Immunol. 2010; 11(10): 920-7. PMID: 20818396.
  17. Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell. 2010; 38(4):500-11. PMID: 20513426; PMC2888511.
  18. Sarkes D, Rameh LE. A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides. Biochem J. 2010; 428(3):375-84. PMID: 20370717.
  19. Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP. Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal 2010; 3(117):ra29. PMID: 20388916.
  20. Rameh LE. Type 2 PIP4-kinases. Chapter 131, In Handbook of Cellular Signaling 2010, Three-Volume Set2 edn (Bradshaw, R.A. and Dennis, E.A., eds), pp1043-1048, Elsevier .
  21. Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 2009; 16(1):21-32. PMID: 19573809; PMC2752826.
  22. Demian DJ, Clugston SL, Foster MM, Rameh L, Sarkes D, Townson SA, Yang L, Zhang M, Charlton ME. High-throughput, cell-free, liposome-based approach for assessing in vitro activity of lipid kinases. J Biomol Screen 2009; 14(7):838-44. PMID: 19641220.
  23. Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadan D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP and Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell  2009; 16 (2): 115-125. PMID: 19647222.
  24. Mallo GV, Smith AC, Terebiznik MR, Aleman A, Finlay BB, Rameh L, Grinstein S & Brumell JH. SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and VPS34. J.Cell Biol. 2008; 182(4): 741-52. PMID: 18725540; PMC2518712.
  25. Mandl A, Sarkes D, Carricaburu V, Jung V & Rameh L. Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN. Mol. Cell Biol. 2007; 27(23):8098-112. PMID: 17893321; PMC2169165.
  26. Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L & Grinstein S. Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. J Gen Physiol. 2007; 129(4):267-83. PMID: 17389247; PMC2151621.
  27. Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC & Ross AH. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol. 2004; 166(2):205-11. PMID: 15249580; PMC2172303.
  28. Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB & Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.  Mol Cell Biol. 2004; 24(11):5080-7. PMID: 15143198; PMC416424.
  29. Chang JD, Field SJ, Rameh LE, Carpenter CL & Cantley LC. Identification and characterization of a phosphoinositide phosphate kinase homolog.  J Biol Chem. 2004;  279(12):11672-9. PMID: 14701839.
  30. Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner CW, Alper SL & Lencer WI. Diarrhea-associated HIV-1 aspartyl protease-inhibitors potentiate muscarinic Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling. Am J Physiol Cell Physiol  2004; 286(5):C998-C1008. PMID: 15075198.
  31. Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC & Rameh LE. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. PNAS 2003; 100: 9867-9872. PMID: 12897244; PMC187868.
  32. Rameh LE. Type 2 PIP4-kinases. In Handbook of Cellular Signaling 2003; Academic Press: pp 129-133.
  33. Field SJ, Lamia KA, Rameh LE, Cantley LC. Lipid research picks up speed on the slopes of Taos. Dev Cell. 2002; 4: 407-10. PMID: 11970891.
  34. Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC & Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol. 2001; 155 19-25. PMID: 11581283; PMC2150784.
  35. Fruman DA, Rameh LE & Cantley LC. Phosphoinositide binding domains: embracing 3-phosphate. Cell 1999; 97: 817-20. PMID: 10399908.
  36. Rameh LE & Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999; 274: 8347-50 PubMed PMID: 10085060.
  37. Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC & Cantley LG. Phosphoinositide 3-kinase regulates Phospholipase Cγ mediated Calcium Signaling.  J. Biol. Chem. 1998; 273: 23750-23757. PMID: 9726983.
  38. Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Cantley LC & Carpenter CL. Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipid Phosphatidylinositol-3,5-bisphosphate.  J. Biol. Chem. 1998; 273: 18040-18046. PMID: 9660759.
  39. Klarlund JK, Rameh LE, Cantley LC, Buxton JM, Holik JJ, Sakelis C, Patki V, Corvera S & Czech MP. Regulation of GRP1-catalyzed ADP Ribosylation Factor guanine nucleotide exchange by phosphatidylinositol-3,4,5-trisphosphate.  J. Biol. Chem. 1998;  273: 1859-1862. PMID: 9442017.
  40. Rameh LE, Tolias KF, Duckworth BC & Cantley LC. A new pathway for phosphatidylinositol-4,5-bisphosphate synthesis.  Nature 1997; 390: 192-195. PMID: 9367159.
  41. Rameh LE, Arvidsson AK, Carraway KL, Couvillon AD, Rathbun G, Crompton A, VanRenterghem B, Czech MP, Ravichandran KS, Burakoff SJ, Wang DS, Chen CS & Cantley LC. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.  J Biol Chem 1997; 272: 22059-22066. PMID: 9268346.
  42. Volker J, Rameh LE, DeCaprio J & Hansen U. Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity. Genes Develop. 1997; 11: 1435-1446. PMID: 9192871.
  43. Rameh LE, Chen C & Cantley LC. Phosphatidylinositol-3,4,5-P3 interacts with SH2 domains and modulates phosphoinositide 3-kinase association with tyrosine-phosphorylated proteins.  Cell 1995; 83: 821-830. PMID: 8521499.
  44. Bachelot C, Rameh, L., Parsons T & Cantley LC. Association of phosphatidylinositol 3-kinase, via the SH2 domains, with the focal adhesion kinase in polyoma middle T-transformed fibroblasts.  Biol. Bioph. Acta. 1996; 1311: 45-52. PMID: 8603102.
  45. Yeh J, Gulves EA, Rameh L & Birnbaum MJ. The effects of wortmannin on rat skeletal muscle. J. Biol. Chem. 1995; 270: 2107-2111.
  46. Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR & Olefsky JM. Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Mol. Cell Biol. 1994; 14: 7466-7475. PMID: 7935461; PMC359282.
  47. Rameh LE & Armelin, MCS. Downregulation of JE and KC by glucocorticoids does not prevent the G0-G1 transition in BALB-3T3 cells. Mol. Cell Biol. 1992; 12:4612-4621. PMID: 1406651; PMC360388.
  48. Rameh LE & Armelin MCS. T antigens role in polyomavirus transformation: c-myc but not c-fos or c-jun expression is a target for middle T.  Oncogenes 1991; 6:1049-1056. PMID: 1648700.
  49. Constanzi E, Rameh LE, Joazeiro CAP, Armelin MCS. Generation of cell lines to study the role played by oncogenes and anti-oncogenes in cell proliferation control. Braz. J. Med. Res.1990; 23: 795-799. PMID: 2101319.

 

Reviews

  1. Rameh LE & Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999; 274: 8347-50 PubMed PMID: 10085060.
  2. Fruman DA, Rameh LE & Cantley LC. Phosphoinositide binding domains: embracing 3-phosphate. Cell 1999; 97: 817-20. PMID: 10399908.

 

Textbook Chapters

  1. Rameh LE. Type 2 PIP4-kinases. In Handbook of Cellular Signaling 2003; Academic Press: pp 129-133.
  2. Rameh LE. Type 2 PIP4-kinases. Chapter 131, In Handbook of Cellular Signaling 2010, Three-Volume Set2 edn (Bradshaw, R.A. and Dennis, E.A., eds), pp1043-1048, Elsevier.