USA Department of Pathology Faculty

Guillermo A. Herrera, M.D.

Locke Eminent Scholar
Professor & Chair, Department of Pathology
Professor, Department of Physiology and Cell Biology

gherrera@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Cytopathology

Education

M.D.: University of Puerto Rico
Anatomic and Clinical Pathology Residency: Brooke Army Medical Center, Ft. Sam Houston, Texas
Internship (Categorical Pathology): Brooke Army Medical Center

Selected Publications

Book Chapters

• Herrera GA, Lott RL: Colloidal gold labeling for diagnostic pathology. In Colloidal Gold: Principles, Methods, and Applications (M.A. Hayat, Ed.) Vol. 3. Academic Press, San Diego and London, 1990, Chapter 16, pp. 321‑345.
• Herrera GA, Turbat‑Herrera EA, Bradley D: Current practices in the immunomorphologic evaluation of tumors in surgical pathology. A comprehensive approach with emphasis on immunolabeling at the light and ultrastructural level. In Electron Microscopic Cytochemistry and Immunocytochemistry in Biomedicine. (T. Barka and K. Ogawa, Eds.). CRC Press Inc., Boca Raton, Florida, 1993, Chapter 19, pp. 739‑780.
• Turbat‑Herrera EA, Harkins L, Herrera GA: Immunoelectron microscopy in diagnostic pathology. In Immunohistochemistry and Immunopathology. Section H, Chapter 50. Manual of Clinical Laboratory Immunology. 5th Ed. (CR Taylor, Ed.) American Society of Microbiology Press, Washington, D.C., 1997, pp. 431‑443.
• Herrera GA, Turbat‑Herrera EA: The state of the art in the diagnosis of mesothelioma. In Sourcebook on Asbestos Diseases, Volume 18. Chapter 10. (G.A. Peters & B. J. Peters, Eds.). Lexis Law Publishing/Reed Elsevier Inc., Charlottesville, VA, 1998, pp. 219‑267.
• Solomon A, Weiss DT, Herrera GA: Light chain deposition disease: clinicopathologic and biologic features. In Myeloma (J. Mehta and S. Singhal, Eds.) Chapter 29. Martin Dunitz Ltd. Pub, Oxford, England, 2002, pp. 507‑518.
• Solomon A, Weiss, DT, Herrera GA: Renal diseases associated with multiple myeloma and related plasma cell dyscrasias. In Biology and Management of Multiple Myeloma (J. Berenson, Ed.) Chapter 14, Humana Press, Totowa, NJ, 2004, pp. 281‑302.
• Herrera GA, Picken MM: Renal diseases associated with plasma cell dyscrasias, amyloidoses, Waldenström macroglobulinemia and cryoglobulinemic nephropathies. In Heptinstall’s Pathology of the Kidney. 7th Ed. Chapter 22 (JC Jennette, JL Olson, FG Silva, and VD D’Agati, Eds). Wolters Kluwer, Philadelphia, Baltimore, New York, London, Hong Kong, Sydney, Tokyo, 2014, pp. 951-1014.
• Iskandar SS, Herrera GA: Organized deposits. In Heptinstall’s Pathology of the Kidney. 7th Ed. Chapter 23 (JC Jennette, JL Olson, FG Silva, and VD D’Agati, Eds.) Wolters Kluwer, Philadelphia, Baltimore, New York, London, Hong Kong, Sydney, Tokyo, 2014, pp. 1015-1037.
• Aufman J, Herrera GA: Renal structural changes in Type 1 and 2 diabetes mellitus: Pathology, pathogenesis, and clinical correlations. In Diabetes and kidney disease (EV Lerma and V Batuman, Eds.), 2014; pp. 39-61.
• Herrera GA, Turbat-Herrera EA: Light / heavy chain deposition disease as a systemic disorder. In Amyloid and related disorders: Surgical Pathology and Clinical Correlations. (MM Picken, A Dogan, GA Herrera, Eds). Current Clinical Pathology series. Humana Press, Springer, New York, NY, 2015, pp. 153-166.
• Herrera GA, Turbat-Herrera EA: Differential diagnosis of amyloid in surgical pathology: Organized deposits and other materials in the differential diagnosis of amyloidosis. In Amyloid and related disorders: Surgical Pathology and Clinical Correlations. (MM Picken, A Dogan, GA Herrera, Eds). Current Clinical Pathology series. Humana Press, Springer, New York, NY, 2015, pp. 135-152.
• Picken MM, Herrera GA: Thioflavin T stain: An easier and more sensitive method for amyloid detection. In Amyloid and related disorders: Surgical Pathology and Clinical Correlations. (MM Picken, A Dogan, GA Herrera, Eds). Current Clinical Pathology series. Humana Press, Springer, New York, NY, 2015, pp. 225-227.
• Herrera GA: Renal diseases associated with hematopoietic disorders or organized deposits. In: Silva’s Diagnostic Renal Pathology (XJ Zhou, Z Laszik, T Nadasdy, VD D’Agati, F Silva Eds.) Cambridge University Press, New York, NY, 2016, pp.385-448.
• Herrera GA: Fibronectin Glomerulopathy. In: Trachtman H., Hogan J., Herlitz L., Lerma E. (eds) Glomerulonephritis. Springer, Cham, 2018. https://doi.org/10.1007/978-3-31927334-1_51-1
• Herrera GA: Collagenofibrotic Glomerulopathy. In: Trachtman H., Hogan J., Herlitz L., Lerma E. (eds) Glomerulonephritis. Springer, Cham, 2018. https://doi.org/10.1007/978-3-319-27334-1_52-1

Publications

The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group.

1. The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH. Nat Rev Nephrol. 2019 Jan;15(1):45-59. doi: 10.1038/s41581-018-0077-4. Review. PMID: 30510265
2. Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage. Herrera GA, Teng J, Zeng C, Xu H, Liang M, Alexander JS, Liu B, Boyer C, Turbat-Herrera EA. Ultrastruct Pathol. 2018 May-Jun;42(3):262-288. doi: 10.1080/01913123.2018.1449772. Epub 2018 Apr 18. PMID: 29668344
3. Animal models of monoclonal immunoglobulin-related renal diseases. Sirac C, Herrera GA, Sanders PW, Batuman V, Bender S, Ayala MV, Javaugue V, Teng J, Turbat-Herrera EA, Cogné M, Touchard G, Leung N, Bridoux F. Nat Rev Nephrol. 2018 Apr;14(4):246-264. doi: 10.1038/nrneph.2018.8. Epub 2018 Feb 19. Review. PMID: 29456245
4. Contribution of human smooth muscle cells to amyloid angiopathy in AL (light-chain) amyloidosis. Vora M, Kevil CG, Herrera GA. Ultrastruct Pathol. 2017 Sep-Oct;41(5):358-368. doi: 10.1080/01913123.2017.1349852. Epub 2017 Aug 10. PMID: 28796568
5. Dendritic cells in renal biopsies of patients with acute tubulointerstitial nephritis. Cheng M, Gu X, Herrera GA. Hum Pathol. 2016 Aug;54:113-20. doi: 10.1016/j.humpath.2016.03.020. Epub 2016 Apr 13. PMID: 27085555
6. Healing the damaged mesangium in nodular glomerulosclerosis using mesenchymal stem cells (MSCs): Expectations and challenges. Herrera GA, Zeng C, Turbat-Herrera EA, Teng J. Ultrastruct Pathol. 2016;40(2):61-70. doi: 10.3109/01913123.2016.1145776. Review. PMID: 27031175
7. Animal Models of Light Chain Deposition Disease Provide a Better Understanding of Nodular Glomerulosclerosis. Herrera GA, Turbat-Herrera EA, Teng J. Nephron. 2016;132(2):119-36. doi: 10.1159/000443282. Epub 2016 Jan 22. PMID: 26794829
8. Circulating monoclonal light chains and acute kidney injury: the role of the renal biopsy with emphasis on ultrastructural evaluation in assessing and understanding renal injury. Aufman J, Herrera GA. Ultrastruct Pathol. 2015 May;39(3):159-68. doi: 10.3109/01913123.2015.1013653. Epub 2015 Apr 9. Review. PMID: 25856088
9. Diagnosis of monoclonal gammopathy of renal significance. Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group. Kidney Int. 2015 Apr;87(4):698-711. doi: 10.1038/ki.2014.408. Epub 2015 Jan 21. Review. PMID: 25607108
10. Proximal tubulopathies associated with monoclonal light chains: the spectrum of clinicopathologic manifestations and molecular pathogenesis. Herrera GA. Arch Pathol Lab Med. 2014 Oct;138(10):1365-80. doi: 10.5858/arpa.2013-0493-OA. PMID: 25268200
11. The many faces of cryoglobulinemic nephropathy: a clinico-pathologic study of 47 cases with emphasis on the value of electron microscopy. Ojemakinde K, Turbat-Herrera EA, Zeng X, Gu X, Herrera GA. Ultrastruct Pathol. 2014 Dec;38(6):367-76. doi: 10.3109/01913123.2014.952803. Epub 2014 Sep 5. PMID: 25191813
12. An animal model of glomerular light-chain-associated amyloidogenesis depicts the crucial role of lysosomes. Teng J, Turbat-Herrera EA, Herrera GA. Kidney Int. 2014 Oct;86(4):738-46. doi: 10.1038/ki.2014.122. Epub 2014 Apr 30. PMID: 24786709
13. Extrusion of amyloid fibrils to the extracellular space in experimental mesangial AL-amyloidosis: transmission and scanning electron microscopy studies and correlation with renal biopsy observations. Teng J, Turbat-Herrera EA, Herrera GA. Ultrastruct Pathol. 2014 Apr;38(2):104-15. doi: 10.3109/01913123.2013.861568. Epub 2014 Jan 24. PMID: 24460740
14. Cheng M, Gu X, Turbat-Herrera EA, Herrera GA: Tubular injury and dendritic cell activation are integral components of light chain-associated acute tubulointerstitial nephritis. Arch Pathol Lab Med, 143:1212-1224, 2019.
15. Lecoq L, Wiegand T, Rodriguez-Alvarez F, Cadalbert R, Herrera GA, del Pozo-Yauner L, Meier BH, Böckmann A: A substantial structural rearrangement leads to in-register parallel amyloid fibril formation in light chain amyloidosis. (In press, Chem Bio Chem, 2019).
16. Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D’Agati V, Dispenzieri A, Fervenza F, Fernand J-P, Gibbs S, D. Gillmore J, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle R, Lachman H, Larsen C, Nasr N: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol, 15(1):45-59, 2019.
17. Ruiz Zamora I R. A, Simon , G, Al-Hilaly Y, Al-Garawi Z, Rodriguez Alvarez FJ, Zavala-Padilla G, Perez-Carreon, JI, Rodriguez-Ambriz SL, Herrera GA, Becerril-Lujan B, Ochoa Leyva A, Melendez-Zajgla J, Serpell L, Del Pozo-Yauner L: The CDR1 and other regions of immunoglobulin light chains are hot spots for amyloid aggregation. Scientific Rep, 9(1):3123-, 2019.
18. Gopinath A, Baskovich B, Alkhasawneh A, Mubeen A, Masood S, Ginn A, Shukri A, Herrera GA: ultrastructural characteristics of gallbladder epithelial inclusions mimicking Cystoisospora. (In press, Am J Clin Pathol, 2019).
19. Royal V, Leung N, Troyanov S, Nasr S, Ecotiere L, LeBlanc R, Adam B, Alexander MP, Angioi A, Asuntis AM, Barraca A, Bianco P, Cohen, C, Drosou ME, Atima H, Fenoglio R, Gougeon F, Goujon J-M, Herrera GA, Knebelmann B, Lepori N, Maletta F, Manso R, Motwani SS, Pani A, Rabant M, Rennke HG, Roccatello D, Rosenblum F, DSanders PW, Sis B, Soto K, Touchard G, Verner CP, Bridoux F: Clinicopathologic predictors of renal outcome in light chain cast nephropathy: A multicenter retrospective study. Blood 135(21):1833-1846, 2020.
20. Mirza, R, Dela Cruz N, Herrera GA: Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with biphasic histology. Case Rep Pathol 2020 Jan 16;2020:3275916. doi: 10.1155/2020/3275916.
21. Herrera GA. The value of ultrastructural evaluation in medical renal diseases. Ultrastruct Pathol. 2019;43(6):225-228. doi: 10.1080/01913123.2019.1696575.
22. Herrera GA, Teng J, Turbat-Herrera EA, Zeng C, Del Pozo-Yauner L. Understanding mesangial pathobiology in AL-Amyloidosis and monoclonal Ig light chain deposition disease. Kidney Int Rep. 2020 Jul 21;5(11):1870-1893. doi: 10.1016/j.ekir.2020.07.013.
23. Herrera GA. Renal amyloidosis with emphasis on the diagnostic role of electron microscopy. Ultrastruct Pathol. 2020 Nov 20;44(4-6):325-341. doi: 10.1080/01913123.2020.1844355. Epub 2020 Nov 9.
24. Howell DN, Herrera GA. Electron microscopy in renal pathology: overall applications and guidelines for tissue, collection, preparation, and stains. Ultrastruct Pathol. 2021 Jan 2;45(1):1- 18. doi: 10.1080/01913123.2020.1854407. Epub 2020 Dec 15.
25. Herrera GA, Del Pozo-Yauner L, Teng J, Zeng C, Shen X, Moriyama T, Ramirez Alcantara V, Liu B, Turbat-Herrera EA. Glomerulopathic light chain-mesangial cell interactions: sortilin- related receptor (SORL1) and signaling. Kidney Int Rep. 2021 Mar 13;6(5):1379-1396. doi: 10.1016/j.ekir.2021.02.014.
26. Herrera GA. Renal amyloidosis: Pathogenesis. Ultrastruct Pathol. 2021 Jul-Sep;45(4-5);267-275.
27. del Pozo-Yauner L, Turbat- Herrera EA, Perez- Carreon JI, Herera GA.From the light chain sequence to the tissue microenvironment: contributions of the mesangial cells to glomerular amyloidosis. Hemato 2022;3(1):232-267.
28. Avalos HS, Manci E, Mulekar M, Finnegan A, Barui S, Galliani C, Kelly D, Herrera GA. Congenital granular cell epulis: 24 new cases with more differences than similarities to granular cell tumor. Ultrastruct Pathol. 2022 Jul 4;46(4):388-400. doi: 10.1080/01913123.2022.2107750.
29. de la Cruz Jasso MA, Mejía-Vilet JM, Del Toro-Cisneros N, Aguilar-León DE, Morales-Buenrostro LE, Herrera G, Uribe-Uribe NO. Leukocyte chemotactic factor 2 amyloidosis (ALECT 2) distribution in a Mexican population: an autopsy study. Am J Clin Pathol. 2023 Jan 4;159(1):89-97.
30. Herrera GA, Teng J, Zeng C, del Pozo-Yauner L, Liu B, Turbat-Herrera EA. AL (light chain)-amyloidogenesis by mesangial cells involves active participation of lysosomes: An ultrastructural study. Heliyon. 2023 Apr 7;9(4):e15190.
31. del Pozo-Yauner L, Herrera GA, Perez-Carreon JI, Turbat-Herrera EA, Rodriguez-Alvarez FJ, Ruiz-Zamora RA. Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: When a friend becomes foe. Front. Immunol.2023 Jun 20;14: doi: 10.3389/fimmu.2023.1203425

Zan Ahmed, M.D

Assistant Professor
Clinical Pathologist

(251) 471-7846
zahmed@health.southalabama.edu

Education

M.D.: Dow International Medical College, Karachi, Pakistan
Residency: University of South Alabama, Mobile, Alabama

Mohammad Barouqa, M.D.

Assistant Professor of Pathology
Director, Blood Bank

(251) 471-7000
mbarouqa@health.southalabama.edu

Board Certifications

American Board of Pathology (Anatomic and Clinical Pathology)

American Board of Hematopathology

Education

Medical Degree: University of Jordan Faculty of Medicine | Amman, Jordan

Residency: Montefiore Medical Center, the University Hospital of Albert Einstein College of Medicine | Bronx, New York

Professional Memberships

Academy of Clinical Laboratory Physicians and Scientists

College of American Pathologists

Debanjan Chakroborty, Ph.D.

Assistant Professor
Member, Cancer Biology Program, Mitchell Cancer Institute

(507) 271-2880
dchakroborty@southalabama.edu

Education

Post-doctoral Research Fellow: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN
Ph.D., Cancer Biology: Chittaranjan National Cancer Institute (Jadavpur University), India
M.S., Zoology: Visva Bharati University, India 

Selected Publications

1. Kakkat S, Pramanik P, Singh S, Singh AP, Sarkar C, Chakroborty D. Cardiovascular Complications in Patients with Prostate Cancer: Potential Molecular Connections. Int J Mol Sci. 2023 Apr 10;24(8):6984. doi: 10.3390/ijms24086984. PMID: 37108147; PMCID: PMC10138415
2. Goswami S, Sarkar C, Singh S, Singh AP, Chakroborty D. Racial differences in prostate tumor microenvironment: implications for disparate clinical outcomes and potential opportunities. Cancer Health Disparities. 2022;6:214. Epub 2022 Dec 31. PMID: 36777283; PMCID: PMC9910060/
3. Chakroborty D, Goswami S, Fan H, Frankel WL, Basu S, Sarkar C. Neuropeptide Y, a paracrine factor secreted by cancer cells, is an independent regulator of angiogenesis in colon cancer. Br J Cancer. 2022 Jul 28. doi: 10.1038/s41416-022-01916-1. Epub ahead of print. PMID: 35902640.
4. Sarkar C, Chakroborty D, Goswami S, Fan H, Mo X, Basu S. VEGF-A controls the expression of its regulator of angiogenic functions, dopamine D2 receptor, on endothelial cells. J Cell Sci. 2022 Jun 1;135(11):jcs259617. doi: 10.1242/jcs.259617.
5. Chakroborty D, Goswami S, Basu S, Sarkar C. Catecholamines in the regulation of angiogenesis in cutaneous wound healing. FASEB J. 2020 Nov;34(11):14093-14102. doi: 10.1096/fj.202001701R. Epub 2020 Sep 19. PMID: 32949437.
6. Sarkar C, Goswami S, Basu S, Chakroborty D. Angiogenesis Inhibition in Prostate Cancer: An Update. Cancers (Basel). 2020 Aug 23;12(9):2382. doi: 10.3390/cancers12092382. PMID: 32842503; PMCID: PMC7564110.
7. Sarkar C, Ganju RK, Pompili VJ, Chakroborty D. Enhanced peripheral dopamine impairs postischemic healing by suppressing angiotensin receptor type 1 expression in endothelial cells and inhibiting angiogenesis. Angiogenesis. 2017;20(1):97-107. doi: 10.1007/s10456-016-9531-8.
8. Chakroborty D, Sarkar C, Lu K, Bhat M, Dasgupta PS, Basu S. Activation of Dopamine D1 receptors in dermal fibroblasts restores vascular endothelial growth factor-A production by these cells and subsequent angiogenesis in diabetic cutaneous wound tissues. Am J Pathol. 2016; 186(9):2262-70. doi: 10.1016/j.ajpath.2016.05.008.
9. Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine is a safe anti-angiogenic drug which can also prevent 5-fluorouracil induced neutropenia. Int J Cancer. 2015;137:744-9. doi: 10.1002/ijc.
10. Joseph M, Das M, Kanji S, Lu J, Aggarwal R, Chakroborty D, Sarkar C, Yu H, Mao H-Q, Basu S, Pompili VJ, Das H. Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. Biomaterials. 2014; 35(30):8566-75. doi: 10.1016/j.biomaterials.2014.06.037
11. Lu K, Chakroborty D, Sarkar C, Lu T, Xie Z, Liu Z, Basu S. Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis. PLoS One. 2012;7(8):e43934. PMID: 22937129.
12. Sarkar C, Chakroborty D, Basu S. Neurotransmitters as regulators of tumor angiogenesis and immunity: The role of catecholamines. J Neuroimmune Pharmacol. 2013;8(1):7-14. PMID: 22886869
13. Chakroborty D, Sarkar C , Yu H, Wang J, Liu Z, Dasgupta PS, Basu S. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U.S.A. 2011;108(51):20730- 20735. PMID: 22143796.
14. Shome S, Rana T, Ganguly S, Basu B, Chaki Choudhury S, Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine regulates angiogenesis in normal dermal wound tissues. PLoS One. 2011;6(9):e25215. PMID: 21949884.
15. Sarkar C, Basu B, Chakroborty D, Dasgupta PS, Basu S. The immunoregulatory role of dopamine: An update. Brain Behav Immun. 2010 May;24(4):525-528. PMID: 19896530.
16. Basu B, Sarkar C, Chakroborty D, Ganguly S, Shome S, Dasgupta PS, Basu S. D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in jurkat T leukemic cells. J Biol Chem. 2010;285(35):27026-27032. PMID: 20592018.
17. Chakroborty D, Sarkar C, Basu B, Dasgupta PS, Basu S. Catecholamines regulate tumor angiogenesis. Cancer Res. 2009 May;69(9):3727-3730. Review. PMID: 19383906
18. Sarkar C, Chakroborty D, Chowdhury UR, Dasgupta PS, Basu S. Dopamine increases the efficacy of anticancer drugs in breast and colon cancer preclinical models. Clin Cancer Res.2008;14(8):2502-2510. PMID: 18413843
19. Chakroborty D, Chowdhury UR, Sarkar C, Baral R, Dasgupta PS, Basu S. Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization. J Clin Invest. 2008;118(4):1380-1389. PMID: 18340382
20. Sarkar C, Das S, Chakroborty D, Chowdhury UR, Basu B, Dasgupta PS, Basu S. Cutting edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation. J Immunol. 2006;177(11):7525-7529. PMID: 17114421. [Cutting Edge]
21. Sarkar C, Chakroborty D, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Dopamine in vivo inhibits VEGF-induced phosphorylation of VEGFR-2, MAPK, and focal adhesion kinase in endothelial cells. Am J Physiol Heart Circ Physiol. 2004 Oct;287:H15554-1560. PMID: 15371263.
22. Basu S, Sarkar C, Chakroborty D, Nagy J, Mitra RB, Dasgupta PS, Mukhopadhyay D. Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis. Cancer Res. 2004;64(16):5551-5555. PMID: 15313889 [Advances in Brief].
23. Chakroborty D, Sarkar C, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Depleted dopamine in gastric cancer tissues: Dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clin Cancer Res. 2004 Jul;10:4349-4356. PMID: 15240521[Featured Article].

Hector Daniel Chavarria-Bernal, M.D. 

Assistant Professor 
Anatomic and Clinical Pathology 

251-471-7799 
hchavarriabernal@health.southalabama.edu 

Board Certifications 

American Board of Anatomical and Clinical Pathology 

Education 

• M.D.: Universidad Dr. José Matías Delgado, San Salvador, El Salvador
• Anatomic and Clinical Pathology Residency: North Shore University Hospital and Long Island Jewish Medical Center; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, New York, NY
• Breast and Gynecological Pathology Fellowship: North Shore University Hospital and Long Island Jewish Medical Center; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, New York, NY
• Genitourinary Pathology Fellowship:  Brigham Women’s Hospital, Harvard Medical School, Boston, MA 

Nestor Dela Cruz, M.D.

Clinical Pathologist
Associate Professor of Pathology

(251) 471-7799
ndelacruz@health.southalabama.edu 

Education

• M.D.: Far Eastern University, Nicanor Medical Center, Institute of Medicine, Manila, Philippines
• Anatomic and Clinical Pathology Residency: Drexel College of Medicine/Hahnemann University Hospital, Philadelphia, PA
• Transfusion Medicine/Blood Bank Fellowship: PennState Health Hershey Medical Center, Hershey, PA
• Surgical Pathology Fellowship: LSU Health Sciences Center, Shreveport, LA

Publications 

“Successful tri-modality treatment of atypical carcinoma ex-pleomorphic adenoma with more than 50 nodal metastases” by FL Ampil, N De La Cruz. (Proceedings of Multidisciplinary Head and Neck Cancer Symposium 2020; lnternat J Radiat Oncol Biol Phys 2020; I 06 abst # 251: I 57). 
 
J Lee, Nestor Dela Cruz, Menchu Ong. “Modifying processing for biopsies less than 5 mm.” 2021. Poster presentation LSU-Shreveport. 
 
“Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL I Protein” Dominik Dabrowski, I Roberto F. Silva,2 Michael Constantinescu,1,3 Rodney E. Shackelford, I Nestor Dela Cruz, I and Eric X. Wei I Case Reports in Oncological Medicine Volume 2020, Article ID 8888829, 7 pages Published 22 December 2020; PMID: 334254 I 2 
 
AR Patil, D S Dabrowski, J Cotelingam, D Veillon, M Ong, N Dela Cruz, E Wei, R Tirupathi, N Ganti, P Vanga,, D Otohinoyi. “Establishing Adrenocortical Carcinoma Specific Prognostic Genes Signature.” Am J of Clinical Patho Vol I 54, p.S148. Issue Supplement Oct 2020 
 
AR Patil, D S Dabrowski, J Cotelingam, D Veillon, M Ong, N Dela Cruz, E Wei, R Tirupathi , P Vanga, A Gundale. “Genomic Analysis Identifies Rare ALK Positive Cases In The TCGA Data Base.” Am J of Clinical Patho Vol 154, pp.S148-S149. Issue Supplement Oct 2020 
 
“Successful tri-modality treatment of atypical carcinoma ex-pleomorphic adenoma with more than 50 nodal metastases" by FLAmpil, N De La Cruz. (Oral Oncol 2019;97:151-152); PMID: 31402212 
 
“Mucosa Schwann Cell Hamartoma in sigmoid colon - A rare case report and review of literature.” Xiuyan Feng*, Hongzhi Xu, Nestor Dela Cruz Human Pathology: Case Reports 19 (2020) 200337 Accepted 19, 
September 2019 
 
Aksionau A, Mirza R, Flowers A, Dela Cruz N. “A unique case of triple malignancy of the head and neck region managed successfully in a single surgery.” J Case Rep Images Pathol 2020;6: I 00032Z I I AA2020. 
 
Rusella Mirza, I Nestor Dela Cruz, I and Guillermo A. Herrera. “Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology.” Hindawi,Case Reports in Pathology, Volume 2020, Article ID PMID: 32015924 
 
Jourdan Rousel, Sudha Pandit, Paul Jordan, Moheb Boktor, Kurt Knowles, Nestor Dela Cruz and Hrishikesh Samant. “Autoimmune Hepatitis (AIH) in Acquired Immune Deficiency Syndrome (AIDS): A case Report and Review of Literature” Hindawi Case Reports in Hepatology Volume 2019, Article ID 5326428 June 9, 2019 PMID: 3 I 28 I 688 
 
F. Ampil, T. Richards, Nestor Dela Cruz, Gloria Caldito. “Predicting Survival with the Heidelberg prognostic model after salvage radiosurgery of previously irradiated progressive high grade gliomas.” Ther Radiol Oncol 25, feb 2019 ppl-4 
 
Hongxi Xu,MD, Guillermo Herrera, MD., Nestor Dela Cruz, MD. “The Role of Electron Microscopy in 
the Diagnosis of Alveolar Proteinosis: A Case Report.” American J. of Clinical Pathology, Vol 150, Sept 2018 
 
Sharma K, Kalakoti P, Shaughnessy JE, Dela Cruz, N, Dossani RH, Zhu P, Gonzalez-Toledo E, Ledbetter, C, Pinkston JB, Nanda, A, Riel-Romero, RM, Minagar A, Notarianni, C, Sun, H: “Psammomatous Cavernous Malformation Presenting as Drug Resistant Epilepsy: Case Illustration and Review of Literature.” World Neurosurgery June 2016 PMID: 27283183 

Santanu Dasgupta, Ph.D.

Assistant Professor
Head, Mitochondria Research Laboratory
Member, Cancer Biology Program, Mitchell Cancer Institute

(251) 445-9805
dasgupta@southalabama.edu 

Education

Postdoctoral Fellow: Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine
Ph.D., Cancer Biology: Chittaranjan National Cancer Institute, West Bengal, India
M.S.: University of Calcutta, West Bengal, India

Selected Publications

1. Hertweck KL, Vikramdeo KS, Galeas JN, Marbut SM, Pramanik P, Yunus F, Singh S, Singh AP, Dasgupta S. Clinicopathological significance of unraveling mitochondrial pathway alterations in non-small-cell lung cancer. FASEB J. 2023 Jul;37(7):e23018. doi: 10.1096/fj.202201724RR. PMID: 37310411.
2. Ibodeng GO, Uche IN, Mokua R, Galo M, Odigwe B, Galeas JN, Dasgupta S. A snapshot of lung cancer: where are we now?-a narrative review. Ann Transl Med. 2023 Mar 31;11(6):261. doi: 10.21037/atm-22-4479. Epub 2023 Feb 6. PMID: 37082671; PMCID: PMC10113107. 
3. Vikramdeo KS, Sharma A, Anand S, Sudan SK, Singh S, Singh AP, Dasgupta S. Mitochondrial Alterations in Prostate Cancer: Roles in Pathobiology and Racial Disparities. Int J Mol Sci. 2023 Feb 24;24(5):4482. doi: 10.3390/ijms24054482. PMID: 36901912; PMCID: PMC10003184. 
4. Haastrup MO, Vikramdeo KS, Singh S, Singh AP, Dasgupta S. The Journey of Mitochondrial Protein Import and the Roadmap to Follow. Int J Mol Sci. 2023 Jan 27;24(3):2479. doi: 10.3390/ijms24032479. PMID: 36768800; PMCID: PMC9916854.
5. Vikramdeo KS, Sudan SK, Singh AP, Singh S, Dasgupta S. Mitochondrial respiratory complexes: Significance in human mitochondrial disorders and cancers. J Cell Physiol. 2022 Sep 8. doi: 10.1002/jcp.30869. Epub ahead of print. PMID: 36074903.
6. Anand S, Vikramdeo KS, Singh S, Singh AP, Dasgupta S. Racial disparities in the genetic landscape of lung cancer. Cancer Health Disparities. 2022;6:210. Epub 2022 Dec 31. PMID: 36819657; PMCID: PMC9937545.
7. Adebayo M, Singh S, Singh AP, Dasgupta S. Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis. FASEB J. 2021;35(6):e21620. PMID: 34048084; PMCID: PMC8415099.
8. Vikramdeo KS, Anand S, Khan MA, Khushman M, Heslin MJ, Singh S, Singh AP, Dasgupta S. Detection of mitochondrial DNA mutations in circulating mitochondria-originated extracellular vesicles for potential diagnostic applications in pancreatic adenocarcinoma. Sci Rep. 2022 Nov 2;12(1):18455. doi: 10.1038/s41598-022-22006-5. PMID: 36323735; PMCID: PMC9630429.
9. Vikramdeo KS, Anand S, Pierce JY, Singh AP, Singh S, Dasgupta S. Distribution of microbiota in cervical preneoplasia of racially disparate populations. BMC Cancer. 2022 Oct 18;22(1):1074. doi: 10.1186/s12885-022-10112-6. PMID: 36258167; PMCID: PMC9578267.
10. Kannan A, Philley JV, Hertweck KL, Ndetan H, Singh KP, Sivakumar S, Wells RB, Vadlamudi RK, Dasgupta S. Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles. Sci Rep. 2019 Aug 12;9(1):11632. doi: 10.1038/s41598-019-48064-w. 
11. Philley JV, Kannan A, Olusola P, McGaha P, Singh KP, Samten B, Griffith DE, Dasgupta S. Microbiome Diversity in Sputum of Nontuberculous Mycobacteria Infected Women with a History of Breast Cancer. Cell Physiol Biochem. 2019;52(2):263-279. doi: 10.33594/000000020. Epub 2019 Feb 28. PMID: 30816674.
12. Olusola P, Banerjee HN, Philley JV, Dasgupta S. Human Papilloma Virus-Associated Cervical Cancer and Health Disparities. Cells. 2019 Jun 21;8(6):622. doi: 10.3390/cells8060622. PMID: 31234354; PMCID: PMC6628030.
13. Philley JV, Kannan A, Olusola P, McGaha P, Singh KP, Samten B, Griffith DE, Dasgupta S. Microbiome Diversity in Sputum of Nontuberculous Mycobacteria Infected Women with a History of Breast Cancer. Cell Physiol Biochem. 2019;52(2):263-279. doi: 10.33594/000000020. Epub 2019 Feb 28. PMID: 30816674.
14. Cervical Cancer Prevention in Racially Disparate Rural Populations. Olusola P, Ousley K, Ndetan H, Singh KP, Banerjee HN, Dasgupta S. Medicines (Basel). 2019 Sep 4;6(3). pii: E93. 
15. Philley JV, Hertweck KL, Kannan A, Brown-Elliott BA, Wallace RJ Jr, Kurdowska A, Ndetan H, Singh KP, Miller EJ, Griffith DE, Dasgupta S. Sputum Detection of Predisposing Genetic Mutations in Women with Pulmonary Nontuberculous Mycobacterial Disease. Sci Rep. 2018 Jul 27;8(1):11336. doi: 10.1038/s41598-018-29471-x. PMID: 30054559; PMCID: PMC6063893.
16.  Kannan A, Hertweck KL, Philley JV, Wells RB, Dasgupta S. Genetic Mutation and Exosome Signature of Human Papilloma Virus Associated Oropharyngeal Cancer. Sci Rep. 2017 Apr 6;7:46102. doi: 10.1038/srep46102. PMID: 28383029; PMCID: PMC5382706.
17. Philley JV, Kannan A, Griffith DE, Devine MS, Benwill JL, Wallace RJ Jr, Brown-Elliott BA, Thakkar F, Taskar V, Fox JG, Alqaid A, Bains H, Gupta S, Dasgupta S. Exosome secretome and mediated signaling in breast cancer patients with nontuberculous mycobacterial disease. Oncotarget. 2017 Mar 14;8(11):18070-18081. doi: 10.18632/oncotarget.14964. PMID: 28160560; PMCID: PMC5392308.
18.  Hertweck KL, Dasgupta S. The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities. Front Oncol. 2017 Nov 2;7:262. doi: 10.3389/fonc.2017.00262. PMID: 29164061; PMCID: PMC5673620.
19. Kannan A, Wells RB, Sivakumar S, Komatsu S, Singh KP, Samten B, Philley JV, Sauter ER, Ikebe M, Idell S, Gupta S, Dasgupta S. Mitochondrial Reprogramming Regulates Breast Cancer Progression. Clin Cancer Res. 2016 Jul 1;22(13):3348-60. doi: 10.1158/1078-0432.CCR-15-2456. Epub 2016 Feb 17. PMID: 26888829.
20. Philley JV, Kannan A, Dasgupta S. MDA-9/Syntenin Control. J Cell Physiol. 2016 Mar;231(3):545-50. doi: 10.1002/jcp.25136. Epub 2015 Oct 7. PMID: 26291527.
21. Duberow DP, Brait M, Hoque MO, Theodorescu D, Sidransky D, Dasgupta S, Mathies RA. High-performance detection of somatic D-loop mutation in urothelial cell carcinoma patients by polymorphism ratio sequencing. J Mol Med (Berl). 2016 Sep;94(9):1015-24. doi: 10.1007/s00109-016-1407-2. Epub 2016 Mar 31. PMID: 27030170; PMCID: PMC8883517.
22. Philley JV, Kannan A, Qin W, Sauter ER, Ikebe M, Hertweck KL, Troyer DA, Semmes OJ, Dasgupta S. Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression. J Cell Physiol. 2016 Jun;231(6):1364-74. doi: 10.1002/jcp.25240. Epub 2015 Nov 24. PMID: 26530043; PMCID: PMC5741292.
23. Oyesanya RA, Bhatia S, Menezes ME, Dumur CI, Singh KP, Bae S, Troyer DA, Wells RB, Sauter ER, Sidransky D, Fisher PB, Semmes OJ, Dasgupta S. MDA-9/Syntenin regulates differentiation and angiogenesis programs in head and neck squamous cell carcinoma. Oncoscience. 2014 Sep 18;1(11):725-737. doi: 10.18632/oncoscience.99. PMID: 25593999; PMCID: PMC4278274.

Arnaud Drouin, M.D.

Assistant Professor of Pathology 

(251) 471-7790 
acdrouin@health.southalabama.edu

Board Certification 

American Board of Pathology 

Education 

M.D.: Faculté de Médecine Broussais-Hôtel Dieu / University Pierre et Marie Curie (Paris VI), Paris, France 
Residency (Clinical Pathology): Beth Israel Deaconess Medical Center, Boston, MA  
Fellowship (Hematopathology): Northwell Health, Lake Success, NY 
Fellowship (Hemostasis & Thrombosis): Beth Israel Deaconess Medical Center, Boston, MA 

Luis del Pozo-Yauner, M.D., Ph.D.

Assistant Professor
Director Clinical Chemistry

(251) 470-5863
ldelpozoyauner@health.southalabama.edu 

Education

M. D.: University of Medical Sciences, Cienfuegos, Cuba.
Clinical Biochemistry Residency: Superior Institute of Medical Science, Villa Clara, Cuba.
Ph.D. Biochemistry: Institute of Biotechnology National Autonomous University of Mexico (UNAM), México.

Publications

• Luis Del Pozo-Yauner, Guillermo A. Herrera, Julio I. Perez-Carreon, Elba A Turbat-Herrera, Francisco J. Rodriguez-Alvarez, Robin A. Ruiz-Zamora. Front. Immunol. Sec. B Cell Biology. Role of the Mechanisms for Antibody Repertoire Diversification in Monoclonal Light Chain Deposition Disorders: When a Friend Becomes Foe. Volume 14 - 2023 | doi: 10.3389/fimmu.2023.1203425
• Guillermo A Herrera, Jiamin Teng, Chun Zeng, Luis Del Pozo-Yauner, Bing Liu, Elba A Turbat-Herrera. AL (light chain)-amyloidogenesis by mesangial cells involves active participation of lysosomes: An ultrastructural study. Heliyon. 2023 Apr 7;9(4):e15190. doi: 10.1016/j.heliyon.2023.e15190. eCollection 2023 Apr.
• Ema Elvira Herrera-López, Dafne Guerrero-Escalera, Isaac Aguirre-Maldonado, Arely López-Hernández, Hilda Montero, María Angélica Gutiérrez-Nava, Luis Del Pozo-Yauner, Jaime Arellanes-Robledo, Javier Camacho, Julio Isael Pérez-Carreón. Annexins A2 and A5 are potential early biomarkers of hepatocarcinogenesis. Sci Rep. 2023 Apr 28;13(1):6948. doi: 10.1038/s41598-023-34117-8.
• Carlos David López-Torres, Julia Esperanza Torres-Mena, María Paulette Castro-Gil, Saúl Villa-Treviño, Jaime Arellanes-Robledo, Luis Del Pozo-Yauner, Julio Isael Pérez-Carreón. Downregulation of indolethylamine N-methyltransferase is an early event in the rat hepatocarcinogenesis and is associated with poor prognosis in hepatocellular carcinoma patients. J Gene Med 2022 Aug;24(8):e3439. doi: 10.1002/jgm.3439. Epub 2022 Jul 24.
• Luis Del Pozo-Yauner, Elba A. Turbat-Herrera, Julio I. Pérez-Carreón, Guillermo A. Herrera. From the Light Chain Sequence to the Tissue Microenvironment: Contribution of the Mesangial Cells to Glomerular Amyloidosis. Hemato 2022, 3(1), 232-267; https://doi.org/10.3390/hemato3010019
• Dafne Guerrero-Escalera, Brisa R. Alarcón-Sánchez, Jaime Arellanes-Robledo, Armando Cruz-Rangel, Luis del Pozo-Yauner, Victoria Chagoya-Hazas, Osbaldo Resendis-Antonio, Saul Villa-Treviño, Julia Esperanza Torres-Mena, Julio Isael Pérez-Carreón. Comparative subcellular localization of NRF2 and KEAP1 during the hepatocellular carcinoma development in vivo. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2022 May;1869(5):119222. doi: 10.1016/j.bbamcr.2022.119222.
• Castro-Gil, M.P., Torres-Mena J.E., Salgado R.M., Muñoz-Montero S.A., Martínez-Garcés, J.M., López-Torres, C.D., Mendoza-Vargas, A., Gabiño-López, N.B., Villa-Treviño, S., Del Pozo-Yauner, L., Arellanes-Robledo, J., Krötzsch, E., Pérez-Carreón, J.I. The transcriptome of early GGT/KRT19-positive hepatocellular carcinoma reveals a downregulated gene expression profile associated with fatty acid metabolism. Genomics (2022) Jan;114(1):72-83. doi: 10.1016/j.ygeno.2021.11.035.
• Maria P. Castro-Gil, Ricardo Sanchez-Rodriguez, Carlos D. Lopez-Torres, Valeria Quintanar-Jurado, Belen Lopez-Gabiño, Saul Viña-Treviño, Luis del Pozo-Yauner, Jaime Arellano-Robledo, Julio I. Perez-Carreon. Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo. Molecular Carcinogenesis; 2021 Jun;60(6):377-390. doi: 10.1002/mc.23298.
• Herrera, G. A., del Pozo-Yauner, L., Teng, J., Zeng, C., Shen, X., Moriyama, T., Ramirez- Alcantara, V., Liu, B., Turbat-Herrera, E.A. Glomerulopathic Light Chain-Mesangial Cell Interactions: Sortilin-Related Receptor (SORL1) And Signaling. Kidney Int Rep. 2021;6(5):1379-1396. DOI: 10.1016/j.ekir.2021.02.014
• Herrera, G.A., Teng, J., Turbat-Herrera, E. A., Zeng, C., del Pozo-Yauner, L. Understanding Mesangial Pathobiology In AL-amyloidosis And Monoclonal Immunoglobulin Light Chain Deposition Disease. Kidney Int Rep (2020) 5, 1870–1893. https://doi.org/10.1016/j.ekir.2020.07.013
• Robin A. Ruiz Zamora, Simon Guillaumé, Youssra Al-Hilaly, Zahraa Al-Garawi, Francisco Javier Rodríguez Alvarez, Guadalupe Zavala-Padilla, Julio I. Pérez Carreón, Sandra L. Rodríguez-Ambriz, Guillermo A. Herrera, Baltazar Becerril-Luján, Adrián Ochoa Leyva, Jorge Melendez-Zajgla, Louise Serpell, Luis del Pozo-Yauner. The CDR1 And Other Regions Of Immunoglobulin Light Chains Are Hot Spots For Amyloid Aggregation. Accepted for publication in Scientific Reports 2019.
• Lauriane Lecoq, Thomas Wiegand, Francisco J. Rodriguez-Alvarez, Riccardo Cadalbert, Guillermo A. Herrera,  Luis del Pozo-Yauner, Beat H. Meier, and Anja Böckmann. A Substantial Structural Conversion of the Native Monomer Leads to In-Register Parallel Amyloid Fibril Formation in Light Chain Amyloidosis. ChemBioChem. 2018 Dec 18. doi: 10.1002/cbic.201800732.
• Torres-Mena JE, Salazar-Villegas KN, Sánchez-Rodríguez R, López-Gabiño B, Del Pozo-Yauner L, Arellanes-Robledo J, Villa-Treviño S, Gutiérrez-Nava MA, Pérez-Carreón JI. Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC. Dig Dis Sci. 2018 Apr;63(4):934-944. doi: 10.1007/s10620-018-4943-5. Epub 2018 Jan 30.
• Fernanda Cornejo-Granados, Zyanya L. Zatarain-Barrón, Vito A. Cantu-Robles, Alfredo Mendoza-Vargas, Camilo Molina-Romero, Filiberto Sánchez, Luis Del Pozo-Yauner, Rogelio Hernández-Pando, Adrián Ochoa-Leyva. Secretome Prediction of Two M. tuberculosis Clinical Isolates Reveals Their High Antigenic Density and Potential Drug Targets. Front. Microbiol. 2017; 8:128. doi: 10.3389/fmicb.2017.00128
• Sánchez SA, Rodríguez Álvarez FJ, Zavala-Padilla G, Mejia-Cristobal LM, Cruz Rangel A, Costas M, Fernández Velasco DA, Melendez-Zajgla J, del Pozo-Yauner L. Stability and aggregation propensity do not fully account for the association of various germline variable domain gene segments with light chain amyloidosis. Biol Chem. 2016 Nov 17. doi: 10.1515/hsz-2016-0178.
• Sánchez-Rodríguez R, Torres-Mena JE, Quintanar-Jurado V, Chagoya-Hazas V, Rojas Del Castillo E, Del Pozo Yauner L, Villa-Treviño S, Pérez-Carreón JI. Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress. Free Radic Biol Med. 2017 Jan;102:87-99. doi: 10.1016/j.freeradbiomed.2016.11.027.
• Shirley Bikel, Alejandra Valdez-Lara, Fernanda Cornejo-Granados, Karina Rico, Samuel Canizales-Quinteros, Xavier Soberón, Luis Del Pozo-Yauner, Adrián Ochoa-Leyva. Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome. Comput Struct Biotechnol J. 2015, 13:390–401
• Sandra Gómez, Laura Adalid-Peralta, Hector Palafox-Fonseca, Vito Adrian Cantu-Robles, Xavier Soberón, Edda Sciutto, Gladis Fragoso, Raúl J. Bobes, Juan P. Laclette, Luis del Pozo Yauner, Adrián Ochoa-Leyva. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR). Scientific Reports 2015, Mayo 5:9683. DOI: 10.1038/srep09683.
• González-Andrade M, Rodríguez-Sotres R, Madariaga-Mazón A, Rivera-Chávez J, Mata R, Sosa-Peinado A, Del Pozo-Yauner L, Arias-Olguín II. Insights into molecular interactions between CaM and its inhibitors from molecular dynamics simulations and experimental data. J Biomol Struct Dyn. 2015 Feb 23:1-39.
• Olga Mata Ruiz, Yolanda Medina Flores, Miying Dessire Gómez Cervantes, Diana Reynada Castillo1, Robin Axel Ruiz Zamora, Francisco Javier Rodríguez Álvarez, Karen Cortes Sarabia, Luis del Pozo Yauner. Generation And Preliminary Characterization of Murine IgM Monoclonal Antibodies against the N-terminal β-strand Of A Fibrillogenic Light Chain Variable Domain. JCBPS; Special Issue, Section C; 30 Nov . 2014 Vol. 4, No. 5, 60-69.
• High-Quality Draft Genomes of Two Vibrio Parahaemolyticus Strains Aid in Understanding Acute Hepatopancreatic Necrosis Disease of Cultured Shrimps in Mexico. Silvia Gomez-Jimenez, Lorena Noriega-Orozco, Rogerio R. Sotelo-Mundo, Vito A. Cantu-Robles, Ana G. Cobian-Guemes, Rosario G. Cota-Verdugo, Luis A. Gamez-Alejo, Luis del Pozo-Yauner, Eduardo Guevara-Hernandez, Karina D. Garcia-Orozco, Alonso A. Lopez-Zavala, Adrián Ochoa-Leyva. Genome Announc. 2014 Aug 14;2(4). pii: e00800-14. doi: 10.1128/genomeA.00800-14.
• García-Magallanes N, Luque-Ortega F, Aguilar-Medina EM, Ramos-Payán R, Galaviz-Hernández C, Romero-Quintana JG, del Pozo-Yauner L, Rangel-Villalobos H, Arámbula-Meraz E. Glucose-6-phosphate dehydrogenase deficiency in northern Mexico and description of a novel mutation. Journal of Genetics, 2014 August 93(2)325-330.
• Sánchez-Rodríguez R, Torres-Mena JE, De-la-Luz-Cruz M, Bernal-Ramos GA, Villa-Treviño S, Chagoya-Hazas V, Landero-López L, García-Román R, Rouimi P, Del Pozo-Yauner L, Meléndez-Zajgla J, Pérez-Carreón JI. Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats. Int J Biochem Cell Biol. 2014 May 20;53C:186-194. doi: 10.1016/j.biocel.2014.05.017.
• del Pozo-Yauner L, Wall JS, González Andrade M, Sánchez-López R, Rodríguez-Ambriz SL, Pérez Carreón JI, Ochoa-Leyva A, Fernández-Velasco DA. The N-terminal strand modulates immunoglobulin light chain fibrillogenesis. Biochem Biophys Res Commun. 2014 Jan 10;443(2):495-9. doi: 10.1016/j.bbrc.2013.11.123.
• Torres Mena JE, Sánchez Rodríguez R, Quintanar Jurado V, Mojica Espinosa R, Del Pozo Yauner L, Meléndez Zajgla J, Villa Treviño S, Pérez Carreón JI. Laser capture microdissection after γ-glutamyl transferase histochemistry: an optimization for gene expression analysis. Anal Biochem. 2014 Feb 15;447:126-32. doi: 10.1016/j.ab.2013.11.015.

Book Chapters

• Herrera, G.A., del Pozo-Yauner, L., Aufman, J.J., Turbat-Herrera, E.A. (2022). Pathogenesis: Structural Changes in the Kidneys in Type 1 and Type 2 Diabetes. In: Lerma, E.V., Batuman, V. (eds) Diabetes and Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-86020-2_6

Osama R. Elkadi, M.D.

Associate Professor
Director, Neuropathology
Director, Residency Program

(251) 471-7790
oelkadi@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Neuropathology
Cytopathology

Education

M.D. Cairo University, Kasr Alainy Faculty of Medicine, Cairo, Egypt 1999-2006
Anatomic and Clinical Pathology Residency, Albany Medical Center, Albany, NY 2010-2014
Neuropathology Fellowship, Oregon Health & Science University (OHSU), Portland, OR 2014-2016
Cytopathology Fellowship, Drexel University, Philadelphia, PA 2017-2018

Publications

• J S Ross, K Wang, Elkadi O, A Tarasen, L Foulke, C E Sheehan, G A Otto, G Palmer, R Yelensky, D Lipson, J Chmielecki, S M Ali, J Elvin, D Morosini, V A Miller, P J Stephens. Next-generation sequencing reveals frequent consistent genomic alterations in small cell undifferentiated lung cancer. Journal of Clinical Pathology  06/2014; 67(9).
• Mneimneh WS, Ashraf MA, Li L, Elkadi O, Qian J, Nazeer T, Hayner-Buchan A. Primary Dural Lymphoma: a Novel Concept of Heterogenous Disease. Pathol Int. 2013 Jan;63(1):68-72.
• Mneimneh WS, Ashraf MA, Elkadi O, Li L, Nazeer T, Homan S. Enteropathy-associated anaplastic large T cell lymphoma ALK-positive (EA-ALCL-ALK+): variant of T cell lymphoma with possible two-hit pathogenesis, J  Hematopathol., 2013 May.
• Igor Sorokin · R C Welliver, Elkadi O, Tipu Nazeer, Ronald P Kaufman. Tumor Seeding of Percutaneous Nephrostomy Tract from Urothelial Carcinoma of the Kidney. Hindawi Publishing Corporation Case Reports in Urology Volume 2013, Article ID 819470

Carlos A. Galliani, M.D.

Professor
Pediatric Pathology Director

(251) 415-1614
cgalliani@health.southalabama.edu

Board Certification

Anatomic and Pediatric Pathology

Education

M.D.: National University of Buenos Aires, Buenos Aires, Argentina
Anatomical Pathology Residency: United Hospitals of St. Paul, St. Paul, MN
Research Associate in Cardiovascular Pathology: United Hospitals of St. Paul, St. Paul, MN
Surgical Pathology Fellowship: University of Minnesota, Minneapolis, MN
Pediatric Pathology Fellowship: Children's Hospital of Los Angeles, Los Angeles, CA

Clinical Expertise

Congenital and Acquired Pediatric Heart Disease, Pediatric Tumors and Cancer Predisposition Syndromes

Kurt J. Knowles, M.D.

Associate Professor
Director, Autopsy

(251) 471-7790
kknowles@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Cytopathology

Education

M.D.: Louisiana State University Health Science Center, Shreveport, LA
United States Naval Aviator, Helicopter Aircraft Commander, Helicopter Combat Support
Flexible Internship: LSU Health Science Center, Shreveport, LA
Pathology Residency: LSU Health Science Center, Shreveport, LA
Cytopathology Fellowship: LSU Health Science Center, Shreveport, LA

Publications

• Knowles KJ, Berkovic J, Gungor A, Al Shaarani M, Lockhart V, Al-Delphi F, Turbat- Herrera EA. Oral foregut duplication cysts: A rare and fascinating congenital lesion. Case report and review of the literature. Am J Otolaryngol. 2017 Nov - Dec; 38 (6):724-725. doi: 10.1016/j.amjoto.2016.11.008. Epub 2016 Nov 23. Review.
• Knowles KJ, Chen S, Herrera GA. Metastatic Colonic Adenocarcinoma to the Extrahepatic Common Bile Duct: The Critical Role of the Pathologist and Immunohistochemistry in Guiding Patient Care Decisions.  Am J Case Rep. 2017 Mar 14; 18:263-7.
• Knowles KJ, Alattia L, Cheng M, Chu Q, Turbat-Herrera EA, Herrera GA. Synchronous Primary Tumors of the Liver and Gallbladder: Case Report and Review of the Literature. Ann Clin Case Rep. 2017; 2: 1407.
• Shi M, Al-Delfi F, Al Shaarani M, Knowles K, Cotelingam J. Ovarian Adenomatoid Tumor Coexisting with Mature Cystic Teratoma: A Rare Case Report. Case Rep Obstet Gynecol. 2017;2017:3702682. doi: 10.1155/2017/3702682. Epub 2017 Sep 11
• Knowles KJ, Wei EX, Seth A, Bienvenu J, Morris J, Manas K, Jordan P, Boktor M. Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature. Case Reports Hepatol. 2017;2017:9627452. doi: 10.1155/2017/9627452. Epub 2017 Dec 3
• Knowles KJ, Al-Delfi F, Abdulsattar J, Lacour R, Black D, Chaudhery S, Turbat-Herrera EA. Malignant granular cell tumors: the role of electron microscopy in the definitive diagnosis of an extremely aggressive soft tissue neoplasm. Ultrastruct Pathol. 2018 May-Jun;42(3):304-311. doi: 10.1080/01913123.2018.1465501. Epub 2018 May 8.
• Kurt J. Knowles, Shoujun Chen, Kathryn Rhymes, Kevin Boykin and Ailing Li. Emperipolesis In A Juvenile Xanthogranuloma: Sentinel Case Report and Review of the Literature
• Knowles KJ, Xu H, Hamiter MJ, Lian TJ, Nathan CO, Li A. Biphenotypic Sinonasal Sarcoma successfully treated with complete excision of the tumor and facial reconstruction with flap: Case report and review of the literature.
• Knowles KJ, Patel KS, Haque M, Alzubaid Y, Li A, Mneimneh WS, Turbat-Herrera EA. Rare and Unusual Tumors of the Head and Neck: Case Reports and Review of the Literature. Am J Otolaryngol Head Neck Surg. 2019; 2(8): 1066.

John J. Lazarchick, M.D.

Adjunct Assistant Professor

(251) 471-7790 

Board Certification

Anatomic and Clinical Pathology
Dermatopathology 

Education

M.D.: University of South Carolina
Anatomic and Clinical Pathology Residency: Emory University
Dermatopathology Fellowship: University of Oklahoma

Carlina Madelaire, M.D.

Assistant Professor

(251) 471-7799
cmadelaire@health.southalabama.edu 

Board Certification

Anatomic Pathology
Cytopathology

Education

Renal and Genitourinary Pathology Fellowship: Louisiana State University Health Science Center, Shreveport, LA
Cytopathology Fellowship: LSU Health Science Center, Shreveport, LA
Surgical Pathology Fellowship: University of Alabama at Birmingham, Birmingham, AL
Anatomic and Clinical Pathology Residency: MetroHealth Medical Center at Case Western Reserve University, Cleveland OH
General Surgery Residency: Santatorio Nosiglia, Argentina
Degree of Physician and Surgeon, National University of the Northeast (UNNE), Corrientes, Argentina

Publications

• LIUY, C Cleveland, Madelaire C. Discordant Immunophenotype of Chronic B Cell Lymphoproliferative Disorder in Simultaneous Specimens from Bone Marrow and Peripheral Sites: A Possible Reflection of Disease Progression and Transformation. Arch Pathol Lab Med 1995; 119:53-58.
• Rhodes RH, Madelaire CN, Petrelli M, Karaman BA. Primary Angiitiss and Angiopathy of the Central Nervous System and Their Relationship to Systemic Giant Cell Arteritis. Arch Pathol Lab Med 1995; 119:334-349.

Poster Presentation

• Discordant Immunophenotype of Chronic B Cell Lymphoproliferative Disorder in Simultaneous Specimens from Bone Marrow and Peripheral Sites: A Possible Reflection of Disease Progression and Transformation. ASCP Meeting, Orlado, FL, 1994

Elizabeth Ann Manci, M.D.

Professor
Director of Pediatric Pathology
Director of Centralized Pathology Unit for Sickle Cell Disease
Director of Alabama Placenta Registry

(251) 415-1612
emanci@health.southalabama.edu

Board Certification

Diplomate of American Board of Pathology (Anatomical Pathology, Clinical Pathology and Pediatric Pathology)

Education

M.D.: University of Alabama College of Medicine
Anatomic and Clinical Pathology Residency: University of Alabama
Anatomic and Clinical Pathology Residency: University of South Alabama

Publications

• Shet AS, Hoffmann TJ, Jirouskova M, Janczak CA, Stevens JR, Adamson A, Mohandas N, Manci EA, Cynober T, Coller BS. Morphological and functional platelet abnormalities in Berkeley sickle cell mice. Blood Cells Mol Dis. 2008 Jul-Aug;41(1):109-18.
• Hsu LL, Champion HC, Campbell-Lee SA, Bivalacqua TJ, Manci EA, Diwan BA, Schimel DM, Cochard AE, Wang X, Schechter AN, Noguchi CT, Gladwin MT. Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood. 2007 Apr 1;109(7):3088-98.
• Manci EA, Hillery CA, Bodian CA, Zhang ZG, Lutty GA, Coller BS. Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease. Blood. 2006 Feb 15;107(4):1651-8.
• Manci EA, Martinez JE, Horenstein MG, Gardner TM, Ahmed A, Mancao MC, Gremse DA, Gardner DM, Nimityongskul P, Maertens P, Riddick L, Kavamura MI. Cardiofaciocutaneous syndrome (CFC) with congenital peripheral neuropathy and nonorganic malnutrition: an autopsy study. Am J Med Genet A. 2005 Aug 15;137(1):1-8.
• Horenstein MG, Manci EA, Walker AB, Dehner LP. Lumbosacral ectopic nephrogenic rest unassociated with spinal dysraphism. Am J Surg Pathol. 2004 Oct;28(10):1389-92.
• Manci EA, Culberson DE, Gardner JM, Brogdon BG, Shah AK, Holladay JE, Powell RW, Mankad VN. Perivascular fibrosis in the bone marrow in sickle cell disease. Arch Pathol Lab Med. 2004 Jun;128(6):634-9.
• Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003 Dec 15;102(13):4582-93.
• Manci EA, Culberson DE, Yang YM, Gardner TM, Powell R, Haynes J Jr, Shah AK, Mankad VN; Investigators of the Cooperative Study of Sickle Cell Disease. Causes of death in sickle cell disease: an autopsy study. Br J Haematol. 2003 Oct;123(2):359-65.
• Mancao MY, Figarola MS, Wilson FM, Manci EA. Detection by CT scan of Penicillium sp. lesions in a patient with B-precursor acute lymphoblastic leukemia. Pediatr Radiol. 2003 Jan;33(1):66-8. Epub 2002 Mar 23.
• Culberson DE, Manci EA, Shah AK, Haynes J, Ballas SK, Pegelow C, Vichinsky E. Nesidioblastosis in sickle cell disease. Pediatr Pathol Mol Med. 2001 Mar-Apr;20(2):155-65.
• Vichinsky EP, Neumayr LD, Earles AN, Williams R, Lennette ET, Dean D, Nickerson B, Orringer E, McKie V, Bellevue R, Daeschner C, Manci EA. Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. N Engl J Med. 2000 Jun 22;342(25):1855-65.
• Mvumbi L, Manci EA, Ulmer RD, Shah AK. Decreased placental and umbilical cord glycogen levels associated with meconium-stained amniotic fluid. Placenta. 1998 May;19(4):295-9.
• Tuohy AM, McKie V, Manci EA, Adams RJ. Internal carotid artery occlusion in a child with sickle cell disease: case report and immunohistochemical study. J Pediatr Hematol Oncol. 1997 Sep-Oct;19(5):455-8.
• Mvumbi L, Manci EA, Ulmer D, Shah AK. Glycogen levels in human term placental disks, umbilical cords, and membranes. Pediatr Pathol Lab Med. 1996 Jul-Aug;16(4):597-605.
• Powell RW, Weber ED, Manci EA. Intradural extension of a sacrococcygeal teratoma. J Pediatr Surg. 1993 Jun;28(6):770-2.
• Gremse DA, Boudreaux CW, Manci EA. Collagenous colitis in children. Gastroenterology. 1993 Mar;104(3):906-9
• Manci EA, Culberson DE, Chen GJ, Mankad V, Joshi VV, Fujimura FK. Polymerase chain reaction facilitates archival autopsy studies of sickle cell disease. Pediatr Pathol. 1993 Jan-Feb;13(1):75-81.
• Saenger JS, Mayer DC, D'Angelo LJ, Manci EA. Ductus-dependent fetal cardiac defects contraindicate indomethacin tocolysis. J Perinatol. 1992 Mar;12(1):41-7.
• Pitt RM, McKelvey TG, Saenger JS, Shah AK, Jones HP, Manci EA, Powell RW. A tungsten-supplemented diet delivered by transplacental and breast-feeding routes lowers intestinal xanthine oxidase activity and affords cytoprotection in ischemia-reperfusion injury to the small intestine. J Pediatr Surg. 1991 Aug;26(8):930-5.
• Manci EA, Coffin CM, Smith SM, Ganong CA. Placental vanadium in gestational diabetes mellitus. Placenta. 1989 Jul-Aug;10(4):417-25.
• Manci EA. Excretion of lead by chronic blood loss. Med Hypotheses. 1988 Jun;26(2):97-8.
• Kvietys PR, Smith SM, Grisham MB, Manci EA. 5-Aminosalicylic acid protects against ischemia/reperfusion-induced gastric bleeding in the rat. Gastroenterology. 1988 Mar;94(3):733-8.
• Manci EA, Maisel DA, Conrad ME. Systemic necrotizing vasculitis in sickle cell disease. Am J Hematol. 1987 Sep;26(1):93-6.
• Manci EA, Blackburn WR. Regional variations in the levels of zinc, iron, copper, and calcium in the term human placenta. Placenta. 1987 Sep-Oct;8(5):497-502.
• Smith SM, Grisham MB, Manci EA, Granger DN, Kvietys PR. Gastric mucosal injury in the rat. Role of iron and xanthine oxidase. Gastroenterology. 1987 Apr;92(4):950-6.
• Manci EA, Gardner WA Jr. Bruch's De Morbis Glandulae Prostatae: an early account of prostatic diseases (1835). Prostate. 1986;8(2):103-21.
• Manci EA, Gardner LL, Pollock WJ, Dowling EA. Osteoclastic giant cell tumor of the pancreas. Aspiration cytology, light microscopy, and ultrastructure with review of the literature. Diagn Cytopathol. 1985 Apr-Jun;1(2):105-10.
• Manci EA, Heath LS, Leinbach SS, Coggin JH Jr. Lymphoma-associated ulcerative bowel disease in the hamster (Mesocricetus auratus) induced by an unusual agent. Am J Pathol. 1984 Jul;116(1):1-8.
• Manci EA, Balch CM, Murad TM, Soong SJ. Polypoid melanoma, a virulent variant of the nodular growth pattern. Am J Clin Pathol. 1981 Jun;75(6):810-5.

Pamela Moore Campbell

Instructor, Pathologists Assistant

(251) 471-7790
pvmoore@health.southalabama.edu 

Jacek M. Polski, M.D.

Professor

Anatomic/Clinical Pathologist and Hematopathologist

Interim Medical Director, Division of Clinical Pathology

(251) 471-7790
jpolski@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Hematopathology

Education

M.D.: Medical Academy of Lublin, Poland
Anatomic and Clinical Pathology Residency: St. Louis University, St. Louis, Missouri
Hematopathology Fellowship: St. Louis University, St. Louis, Missouri 

Selected Publications

• Fahmawi Y, Campos Y, Khushman M, Alkharabsheh O, Manne A, Zubair H, Haleema S, Polski J, Bessette S. Vitamin B12 deficiency presenting as pseudo-thrombotic microangiopathy: a case report and literature review. Clin Pharmacol 11:127-131. 2019 Aug.
• Ayar SP, Ravula S, Polski JM:  Granulocyte, Monocyte and Blast Immunophenotype Abnormalities in Acute Myeloid Leukemia with Myelodysplasia-Related Changes. Ann Clin Lab Sci 44(1):3-9. 2014 Winter.
• Polski JM:  Controversies in the Current Hematopathology Practice and Classification of Hematopoietic and Lymphoid Neoplasms (Editorial). Ann Clin Pathol 2(1):1008. Jan. 2014.
• Arora A, Imran H, Wilson F., Polski J, Siddiqui A. T-Cell Acute Lymphoblastic Leukemia Complicated by a Hemorrhagic Stroke and Hemophagocytic Lymphohistiocytosis. Journal of Investigative Medicine 61(2):403. 2013 Febr.
• Papadi B, Polski JM, Clarkson DR, Liu-Dumlao TO:  Atypical Angioimmunoblastic T-Cell Lymphomas Masquerading as Systemic Polyclonal B-Immunoblastic Proliferation.  Virchows Archives 461(3):323-31, 2012 Sep.
• Goel S, Polski JM, Imran H. Sensitivity and specificity of bone marrow hemophagocytosis in hemophagocytic lymphohistiocytosis.  Ann Clin Lab Sci 42(1):21-5. 2012 Winter.
• Zuo Z, Polski JM, Kasyan A, Medeiros LJ: Acute Erythroid Leukemia.  Arch Pathol Lab Med 134(9):1261-70. Sept. 2010.
• Ravine TJ, Polski JM, Jenkins J. Recognition of Naegleriae ameba surface protein epitopes by anti-human CD45 antibodies. Cytometry A. 2010 Apr;77(4):305-9.
• Estrada B, Mancao MY, Polski JM, Figarola MS. Candida lusitaniae and chronic granulomatous disease. Pediatr Infect Dis J. 2006 Aug;25(8):758-9.
• Polski JM, Spreen AN. Pacinian corpuscle in human lymph node. Lymphology. 2005 Mar;38(1):18-9.
• Polski JM, Dunphy CH, Evans HL, Brink DS. Lymph node infarction. Arch Pathol Lab Med. 2003 Aug;127(8):922.
• Dunphy CH, Galambos C, Polski JM, Evans HL, Gardner LJ, Grosso LE, Montone KT. Extranodal posttransplant plasmacytic hyperplasia with subsequent posttransplant plasmacytic malignancy: six-year interval case report and review of the literature. Arch Pathol Lab Med. 2002 Mar;126(3):351-6.
• Polski JM, Galambos C, Gale GB, Dunphy CH, Evans HL, Batanian JR. Acute megakaryoblastic leukemia after transient myeloproliferative disorder with clonal karyotype evolution in a phenotypically normal neonate. J Pediatr Hematol Oncol. 2002 Jan;24(1):50-4.
• Dunphy CH, Polski JM, Evans HL, Gardner LJ. Evaluation of bone marrow specimens with acute myelogenous leukemia for CD34, CD15, CD117, and myeloperoxidase. Arch Pathol Lab Med. 2001 Aug;125(8):1063-9.
• Gardner LJ, Polski JM, Evans HL, Perkins SL, Dunphy CH. CD30 expression in follicular lymphoma. Arch Pathol Lab Med. 2001 Aug;125(8):1036-41.
• Dunphy CH, Polski JM, Johns G, Evans HL, Gardner LJ. Acute promyelocytic leukemia, hypogranular variant, with uncharacteristic staining with chloroacetate esterase. Leuk Lymphoma. 2001 Jun;42(1-2):215-9.
• Polski JM, Brunt EM, Saeed ZA. Chronology of histological changes after band ligation of esophageal varices in humans. Endoscopy. 2001 May;33(5):443-7.
• Dunphy CH, Polski JM, Lance Evans H, Gardner LJ. Paraffin immunoreactivity of CD10, CDw75, and Bcl-6 in follicle center cell lymphoma. Leuk Lymphoma. 2001 May;41(5-6):585-92.
• Evans HL, Polski JM, Deshpande V, Dunphy CH. CD5+ true SLL/CLL with plasmacytic differentiation and an unusual 1p36 translocation: case report and review of the literature. Leuk Lymphoma. 2000 Nov;39(5-6):625-32.
• Polski JM, Galvin N, Salinas-Madrigal L. Non-amyloid fibrils in heavy chain deposition disease. Kidney Int. 1999 Oct;56(4):1601-2.
• Polski JM, Janney CG. Ber-H2 (CD30) immunohistochemical staining in malignant melanoma. Mod Pathol. 1999 Sep;12(9):903-6.
• Suarez AA, Polski JM, Grossman BJ, Johnston MF. Blood transfusion-acquired hemoglobin C. Arch Pathol Lab Med. 1999 Jul;123(7):642-3.
• Polski JM, Creer MH, Ritter D, Johnston MF. Polyethylene glycol-induced immunoglobulin precipitation may cause invalidation of antiglobulin tests. Transfusion. 1999 May;39(5):537-9.
• Polski JM, Kimzey S, Percival RW, Grosso LE. Rapid and effective processing of blood specimens for diagnostic PCR using filter paper and Chelex-100. Mol Pathol. 1998 Aug;51(4):215-7.
• Gardner LJ, Polski JM, Fallon R, Dunphy CH. Identification of CD56 and CD57 by flow cytometry in Ewing's sarcoma or primitive neuroectodermal tumor. Virchows Arch. 1998 Jul;433(1):35-40. 

Chandrani Sarkar, Ph.D.

Assistant Professor
Member, Cancer Biology Program, Mitchell Cancer Institute

(251) 445-9871
csarkar@southalabama.edu 

Education

Post-doctoral Research Fellow: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN
Ph.D., Cancer Biology: Chittaranjan National Cancer Institute (Jadavpur University), India
M.S., Applied Clinical and Preclinical Research (MACPR): The Ohio State University, Columbus, OH
M.S., Zoology: Visva Bharati University, India 

Selected Publications

1. Kakkat S, Pramanik P, Singh S, Singh AP, Sarkar C, Chakroborty D. Cardiovascular Complications in Patients with Prostate Cancer: Potential Molecular Connections. Int J Mol Sci. 2023 Apr 10;24(8):6984. doi: 10.3390/ijms24086984. PMID: 37108147; PMCID: PMC10138415.
2. Goswami S, Sarkar C, Singh S, Singh AP, Chakroborty D. Racial differences in prostate tumor microenvironment: implications for disparate clinical outcomes and potential opportunities. Cancer Health Disparities. 2022;6:214. Epub 2022 Dec 31. PMID: 36777283; PMCID: PMC9910060.
3. Chakroborty D, Goswami S, Fan H, Frankel WL, Basu S, Sarkar C. Neuropeptide Y, a paracrine factor secreted by cancer cells, is an independent regulator of angiogenesis in colon cancer. Br J Cancer. 2022 Jul 28. doi: 10.1038/s41416-022-01916-1. Epub ahead of print. PMID: 35902640.
4. Sarkar C, Chakroborty D, Goswami S, Fan H, Mo X, Basu S. VEGF-A controls the expression of its regulator of angiogenic functions, dopamine D2 receptor, on endothelial cells. J Cell Sci. 2022 Jun 1;135(11):jcs259617. doi: 10.1242/jcs.259617. 
5. Chakroborty D, Goswami S, Basu S, Sarkar C. Catecholamines in the regulation of angiogenesis in cutaneous wound healing. FASEB J. 2020 Nov;34(11):14093-14102. doi: 10.1096/fj.202001701R. Epub 2020 Sep 19. PMID: 32949437.
6. Sarkar C, Goswami S, Basu S, Chakroborty D. Angiogenesis Inhibition in Prostate Cancer: An Update. Cancers (Basel). 2020 Aug 23;12(9):2382. doi: 10.3390/cancers12092382. PMID: 32842503; PMCID: PMC7564110.
7. Sarkar C, Ganju RK, Pompili VJ, Chakroborty D. Enhanced peripheral dopamine impairs postischemic healing by suppressing angiotensin receptor type 1 expression in endothelial cells and inhibiting angiogenesis. Angiogenesis. 2017;20(1):97-107. doi: 10.1007/s10456-016-9531-8.
8. Chakroborty D, Sarkar C, Lu K, Bhat M, Dasgupta PS, Basu S. Activation of Dopamine D1 receptors in dermal fibroblasts restores vascular endothelial growth factor-A production by these cells and subsequent angiogenesis in diabetic cutaneous wound tissues. Am J Pathol. 2016; 186(9):2262-70. doi: 10.1016/j.ajpath.2016.05.008.
9. Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine is a safe anti-angiogenic drug which can also prevent 5-fluorouracil induced neutropenia. Int J Cancer. 2015;137:744-9. doi: 10.1002/ijc.
10. Joseph M, Das M, Kanji S, Lu J, Aggarwal R, Chakroborty D, Sarkar C, Yu H, Mao H-Q, Basu S, Pompili VJ, Das H. Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. Biomaterials. 2014; 35(30):8566-75. doi: 10.1016/j.biomaterials.2014.06.037
11. Lu K, Chakroborty D, Sarkar C, Lu T, Xie Z, Liu Z, Basu S. Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis. PLoS One. 2012;7(8):e43934. PMID: 22937129.
12. Sarkar C, Chakroborty D, Basu S. Neurotransmitters as regulators of tumor angiogenesis and immunity: The role of catecholamines. J Neuroimmune Pharmacol. 2013;8(1):7-14. PMID:22886869
13. Chakroborty D, Sarkar C , Yu H, Wang J, Liu Z, Dasgupta PS, Basu S. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U.S.A. 2011;108(51):20730- 20735. PMID: 22143796.
14. Shome S, Rana T, Ganguly S, Basu B, Chaki Choudhury S, Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine regulates angiogenesis in normal dermal wound tissues. PLoS One. 2011;6(9):e25215. PMID: 21949884.
15. Sarkar C, Basu B, Chakroborty D, Dasgupta PS, Basu S. The immunoregulatory role of dopamine: An update. Brain Behav Immun. 2010 May;24(4):525-528. PMID: 19896530.
16. Basu B, Sarkar C, Chakroborty D, Ganguly S, Shome S, Dasgupta PS, Basu S. D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in jurkat T leukemic cells. J Biol Chem. 2010;285(35):27026-27032. PMID: 20592018.
17. Chakroborty D, Sarkar C, Basu B, Dasgupta PS, Basu S. Catecholamines regulate tumor angiogenesis. Cancer Res. 2009 May;69(9):3727-3730. Review. PMID: 19383906
18. Sarkar C, Chakroborty D, Chowdhury UR, Dasgupta PS, Basu S. Dopamine increases the efficacy of anticancer drugs in breast and colon cancer preclinical models. Clin Cancer Res.2008;14(8):2502-2510. PMID: 18413843
19. Chakroborty D, Chowdhury UR, Sarkar C, Baral R, Dasgupta PS, Basu S. Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization. J Clin Invest. 2008;118(4):1380-1389. PMID: 18340382
20. Sarkar C, Das S, Chakroborty D, Chowdhury UR, Basu B, Dasgupta PS, Basu S. Cutting edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation. J Immunol. 2006;177(11):7525-7529. PMID: 17114421. [Cutting Edge]
21. Sarkar C, Chakroborty D, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Dopamine in vivo inhibits VEGF-induced phosphorylation of VEGFR-2, MAPK, and focal adhesion kinase in endothelial cells. Am J Physiol Heart Circ Physiol. 2004 Oct;287:H15554-1560. PMID: 15371263.
22. Basu S, Sarkar C, Chakroborty D, Nagy J, Mitra RB, Dasgupta PS, Mukhopadhyay D. Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis. Cancer Res. 2004;64(16):5551-5555. PMID: 15313889 [Advances in Brief].
23. Chakroborty D, Sarkar C, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Depleted dopamine in gastric cancer tissues: Dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clin Cancer Res. 2004 Jul;10:4349-4356. PMID: 15240521 [Featured Article].

Mohamed Shaban, Ph.D., SMIEEE

Assistant Professor, Electrical and Computer Engineering
Assistant Professor (Joint), Pathology

(251) 460-7154
mshaban@southalabama.edu

Jiamin Teng M.D., Ph.D.

Associate Professor of Clinical Research

Office: (251) 460-7608
Lab: (251) 460-7609
jteng@health.southalabama.edu 

Education

M.D.: Changzhi Medical College, Changzhi, China
Master of Medical Science: Tongji Medical University, Wuhan, China
Ph.D.: Nihon University School of Medicine, Tokyo, Japan
Post-Doctoral Fellowship: Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA

Book Chapters / Meeting Proceedings

1. Herrera, GA, Turbat-Herrera,  EA, Teng. J: Mesangial homeostasis  and pathobiology: Their role in health and disease. In Experimental models for renal diseases: impact on understanding pathogenesis and improving diagnosis. (GA Herrera, Ed). Contributions  to Nephrology series. S. Karger A.G., Basel, Switzerland. pp 6-22. 2011
2. Herrera, GA, Turbat-Herrera, EA, Teng. J: Renal amyloidosis: Current views on pathogenesis and impact on diagnosis. In Experimental models for renal diseases: impact on understanding pathogenesis and improving diagnosis. (GA Herrera, Ed) Contributions  to Nephrology series. S. Karger A.G., Basel, Switzerland   Pp 232-246. 2011
3. Herrera, GA, Turbat-Herrera, EA,  Teng. J: Glomerular  repair: Current status and future expectations. In Experimental models for renal diseases: impact on understanding pathogenesis and improving diagnosis. (GA Herrera, Ed). Contributions  to Nephrology series. S. Karger A.G., Basel, Switzerland. pp 351-362.2011
4. Teng J. Herrera GA: Mesangial amyloid formation in an isolated rat kidney perfusion model: A new model to study renal amyloidogenesis.  In Xlth International Symposium on Amyloidosis (M. Skinner, JL Berk, LH Connors, DC Seldin, Eds). CRC Press, Taylor and Francis Group,  Boca Raton, London, New York, pp. 307-309. 2008
5. Herrera GA, Keeling J,  Teng J: Pathogenesis of renal AL-amyloidogenesis (AL-Am): An in-vitro approach to understanding mechanisms involved.   In Amyloid and Amyloidosis. (G Grateau, RA Kyle, M Skinner, Eds.) CRC Press, Boca Raton, London, New York, Washington DC, pp. 139-141.  2005
6. Hayagawa, S. Karasaki, B. Teng. J. Basic for the molecular biological experiment.  In: Research Compass for Obstetrics and Gynecologist,  K. Satoh (Eds.) Tokyo: Medical View Press, pp. 283-292. 1998.

Journal Publications, Including Manuscripts And Editorials

1. Herrera GA, Jiamin Teng, Chun Zeng, Hongzhi Xu, Man Liang and Elba A. Turbat-Herrera, Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin  light chain associated mesangial damage. Nephron. Submitted.
2. Herrera GA, Zeng C, Turbat-Herrera EA, Teng J: Healing the damaged mesangium  in nodular glomerulosclerosis using mesenchymal stem cells (MSCs): Expectations and challenges. Ultrastructure Pathology. 2016 40(2), 61-70,
3. Herrera GA, Turbat-Herrera EA, Teng J: Animal models of light  chain deposition disease provide  a better  understanding of nodular glomerulosclerosis. Nephron  132(2):119-136, 2016
4. Herrera GA, Turbat-Herrera EA, Teng J: Understanding mesangial damage and repair: Insights  from an experimental model of immunoglobulin light chain-associated mesangiopathy Journal of Cell Biology and Cell Metabolism 2014 1(1): 002-011
5. Teng J, Herrera  GA, Liu X, Zhang  Y, Turbat-Herrera EA: Mesenchymal stem cells  in mesangial repair in a model of light chain-mediated mesangial injury. J Stem Cell Res Ther  4:215-227, 2014. doi:10.4172/2157-7633.1000215.
6. Teng. J. Herrera, E. Herrera,  GA. An animal model of glomerular light­ chain-associated amyloidogenesis depicts  the crucial role of lysosomes Kidney Int. 86(4):738-46. doi: 10.1038/ki. 2014.122. Oct. 2014
7. Teng. J. Herrera, E. Herrera,  GA. Extrusion of amyloid  fibrils  to the extracellular space in experimental mesangial AL-amyloidosis: Transmission and scanning electron  microscopy studies  and correlation with renal biopsy  observations. Ultr£1$lrvcLE&hoL; 38(2):104-15. Apr. 2014
8. G. A. Herrera, E. A. Turbat-Herrera, &  Teng. J. Mesangial homeostasis and pathobiology: their role in health and disease. Contrib  Nephrol 2011 20;169:6-22. Epub  Jan 20. 2011
9. G. A. Herrera, Teng. J. , & E. A. Turbat-Herrera. Renal amyloidosis: current views  on pathogenesis and impact  on diagnosis. Contrib  Nephrol 2011 20;169:232-46. Epub Jan 20.2011
10. G. A. Herrera, E. A. Turbat-Herrera, &  Teng. J. Glomerular repair: present status and future expectations. Contrib  Nephrol2011 20;169:351-62. Epub   Jan 20. 2011
11. G. A. Herrera, E. A. Turbat-Herrera, &  Teng. J. Animal model  of renal AL­amyloidogenesis recapitulates in vitro findings.  Amyloid. 18 Suppl1:34-7. 2011
12. Teng. J., Herrera, GA, Mesangial amyloid  formation in an isolated rat kidney  perfusion model: A new model to study renal amyloidogenesis. Xlth international symposium on amyloidosis. Martha  Skinner,  John L. Berk, Lawreen H. Connors, David C. Seldin (Eds) CRC Press,  pp.307-309, 2007
13. Teng. J. Herrera, E. Herrera, GA. The role of translational research advancing the understanding of the pathogenesis of light chain mediated glomerulopathies. Pathology International 57: 398-412. 2007
14. Herrera, GA, Keeling,  J, Teng. J., Pathogenesis of renal al-amyloidosis: an in vitro approach to understanding mechanisms involved. Amyloid and Amyloidosis. Gilles Grateau,  Robert A. Kyle, Martha  Skinner (Eds) CRC Press, pp.139-141, 2004
15. Zhang,  PL.,   Lun, M., Teng, J., Huang, J., Blasick, TM., Yin, L., Herrera, GA. and Cheung, JY., Preinduced Molecular Chaperones in the Endoplasmic Reticulum Protect Cardiomyocytes from Lethal Injury. Annals of Clinical & Laboratory Science  34:449-457. 2004
16. Keeling, J, Teng, J. Herrera,  GA, AL-amyloidosis and light-chain deposition disease  light chains induce  divergent phenotypic transformations of human mesangial cells. Laboratory Investigation 84:1322-1338.2004
17. Teng. J, Russell, WJ.,Gu, X., Cardelli, C., Jones,  ML.,  and Herrera, GA., Different types of glomerulopathic light chains  interact  with mesangial cells using a common receptor  but exhibit different  intracellular trafficking patterns. Laboratory Investigation 84: 440-451. 2004
18. Teng. J, Zhang,  PL, Russell,  WJ., Zheng, LP., Herrera,  GA., Insights into mechanisms responsible for mesangial alterations associated with fibrogenic glomerulopathic light chains.  Nephron physiology, 94: 28-38, 2003
19. Hayagawa. S. Karasaki, B.  Teng. J. Basic for the molecular  biological experiment. In: Research Compass for Obstetrics and Gynecologist, K. Satoh (Eds.) Tokyo: Medical View Press. pp. 283-292. 1998.
20. Teng. J, Tochigi. M. and Satoh, K. Reverse effects of PGE2on ovulation inhibited by Indomethacin  or/and Nordihydro-guaiaretic acid in mice. Nihon Univ. J. Med. 39(4): 187-202, 1997.
21. Satoh, K., Tochigi. M. and Teng. J. Endometriosis and Pain: the role of prostaglandins. In: Endometriosis Today-Advances in research and practice, The Proceedings  of the 5" World Congress on Endometriosis,  Yokohama. Japan. October, 1996. Published in the International Congress. Symposium and Seminar Series (I.C.S.S) 13: 75-79, 1997.
22. Tochigi, M. Hayagawa. S. Teng. J. and Satoh, K. Recurring spontaneous pneumothorax accompanied  with menstruation due to endometriosis  of the diaphragma. J. Endometriosis  Research. 17: 120-123. 1996.
23. Teng J., Tochigi, M. and Satoh. K. Role of eicosanoids in ovulation. Nihon Univ. J. Med. 37(5): 249-262, 1995.
24. Xiong C. Teng J. Effect of Succinate dehydrogenase on sperm livability. Chinese Journal of Andrology  8 (03):  138-42, 1994
25. Teng J. Xia, W. and Wu, X. Synergistic effects of injectio leonuri with 15-methyi­ PGF2tc methyl ester and sulprostone on rabbits' myometrium. Acta University Medicinae Tongji, 21(2): 103-5, 1992.

Elba A. Turbat-Herrera, M.D.

Professor, MCI Interdisciplinary Clinical Oncology
Director, MCI Pathological Services
Director, USA Health Biobank

(251) 471-7790
etherrera@health.southalabama.edu 

Board Certifications

American Board of Pathology in Anatomic and Clinical Pathology
American Board of Pathology Special Certification in Cytopathology

Education

M.D.: University of Alabama, Birmingham   
University of Alabama, Birmingham: Pathology Residency (1985-1988)
Mount Sinai Medical Center, Miami Beach, Florida: Pathology Residency (1988-1989)
University of Mississippi Medical Center: Fellowship, Cytopathology
University of Alabama, Birmingham: Fellowship, Molecular Biology of HPV

Selected Publications

1. Wellikoff AS, Holladay RC, Downie GH, Chaudoir CS, Brandi L, Turbat-Herrera EA. Comparison of in vivo probe-based confocal laser endomicroscopy with histopathology in lung cancer: A move toward optical biopsy. Respirology. 2015 Aug;20(6):967-74.
2. Herrera GA, Turbat-Herrera EA, Teng J: Animal models of light chain deposition disease provide a better understanding of nodular glomerulosclerosis. Nephron 132:119-136, 2016.
3. Herrera GA, Zeng C, Turbat-Herrera EA, Teng J: Healing the damaged mesangium in nodular glomerulosclerosis using mesenchymal stem cells (MSCs): Expectations and challenges. Ultrastruct. Pathol 40:61-70, 2016.
4. Vora M, Lacour RA, Black DR, Turbat-Herrera EA ,Gu X: Neuroendocrine  tumors in the ovary: histogenesis, pathologic differentiation, and clinical presentation. See comment in PubMed Commons belowArch Gynecol Obstet. Mar;293(3):659-65 ,2016.
5. Knowles KJ, Berkovic J, Gungor A, Al Shaarani M, Lockhart V, Al-Delphi F, Turbat-Herrera EA.: Oral foregut duplication cysts: A rare and fascinating congenital lesion. Case report and review of the literature Am J Otolaryngol. 2016 Nov 23.  [Epub ahead of print].
6. Herrera GA, Teng J, Zeng C, Turbat-Herrera EA1: Plasticity of mesenchymal stem cells (MSCs) in mesangial repair: The crucial role of electron microscopy (EM) monitoring and understanding the process. Ultrastruct Pathol. 2017 Jan-Feb;41(1):97.
7. Flowers A, Turbat-Herrera EA. EM proves invaluable in the confirmation of chordoma in the sacral mass of a middle aged man Ultrastruct  Pathol 41, p258-263, 2017.
8. Herrera GA, Turbat-Herrera EA, Teng J, Liu B, Rodriguez-Alvarez F, Pozo-Yauner L: Understanding lambda 6 light chain fibrillogenesis/translational application to renal biopsy. Lab Invest 97A:407A, 2017; Mod Pathol 30:407A, 2017.
9. Herrera GA, Teng J, Turbat-Herrera EA: Receptor on mesangial cells for glomerulopathic light chains: the search continues.  Mod Pathol 2018 March; 31(S2):613.
10. Sirac C, Herrera GA, Sanders P, Batuman V, Bender S, Ayala M, Javavue V, Teng J, Turbat-Herrera EA, Cogne M, Touchard G, Leung N, Bridoux F: Animal models of monoclonal immunoglobulin –related renal diseases. Nat Rev Nephrol, 14(4):246-264, 2018.
11. Al Shaarani M, Abdulsatter J, Cotelingam J, Coppola D, Turbat-Herrera EA, Shackelford RE. Nicotinamide Phosphoribosyl Transferase Immunohistochemistry Differentiates thyroid follicular carcinomas from follicular adenomas, Herrera GA, Teng J, Zeng C, Xu H, Liang M, Turbat-Herrera EA:  Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage.  Ultrastruct Pathol 42:3:246-254, 2018.
12. Herrera GA, Teng J, Zeng C, Xu H, Liang M, Turbat-Herrera EA: Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage. Ultrastruct Pathol 42(3):246-254, 2018.
13. Wei E, Chen S, Turbat-Herrera EA, Herrera GA, Chadha M, Shackelford R: Metastatic TFE3-overexpressing renal clear cell carcinoma with dense granules: a histological, immunohistochemical, and ultrastructural study. Ultrastruct Pathol 42(4):369-375, 2018.
14. Cheng M, Gu X, Turbat-Herrera EA, Herrera GA: Tubular injury and dendritic cell activation are integral components of light chain-associated acute tubulointerstitial nephritis. (In press, Arch Pathol Lab Med, 2019).

Eric X. Wei, M.D, Ph.D.

Associate Professor

(251) 471-7790
ewei@health.southalabama.edu 

Board Certifications

Anatomic and Clinical Pathology
Hematopathology

Education

M.D.: Shanghai Medical College Fudan University, Shanghai, China
M.S.: Ohio State University, Columbus, OH
Ph.D.: Johns Hopkins University School of Medicine, Baltimore, MD
Computer Science: Palomar College and California State University San Marcos
Anatomic and Clinical Pathology Residency: LSU Health Sciences Center, Shreveport, LA 
Hematopathology Fellowship: MD Anderson Cancer Center, Houston, TX

Selected Publications

1. Aksionau A, Wei EX.  Accuracy of the Criteria for Hemophagocytic Lymphohistiocytosis.  Int J Clin Exp Pathol. 2020 Dec 1;13(12):3139-3148. eCollection 2020.
2. Dabrowski D, Ozluk E, Barbieto S, Wei EX.  Focal Segmental Glomerulosclerosis Preceding Papillary Renal Cell Carcinoma Type 2.  Case Rep Pathol. 2020 Oct 15;2020:8811905. doi: 10.1155/2020/8811905. eCollection 2020.
3. Dabrowski D, Silva RF, Constantinescu M, Shackelford RF, Dela Cruz N, Wei EX.  Synchronous Occurrence of Splenic Pleomorphic Mantle cell Lymphoma and esophageal adenocarcinoma with overexpression of BCL1 Protein.  Case Rep Oncol Med. 2020 Dec 21;2020:8888829. doi: 10.1155/2020/8888829. eCollection 2020.
4. Al Shaarani M, Shackelford RE, Master SR, Mills GM, AlZubaidi Y, Mamilly A, Wei EX. Plasmablastic Lymphoma, a Rare Entity in Bone Marrow with Unusual Immunophenotype and Challenging Differential Diagnosis.  Case Rep Hematol Volume 2019, Article ID 1586328.  https://doi.org/10.1155/2019/1586328
5. Mirza R, Wei EX.  A giant parathyroid tumor during pregnancy: adenoma versus carcinoma.  Case Rep Pathol Jun 13;2019:4383698. doi: 10.1155/2019/4383698. eCollection 2019.
6. Kim D, Chen J, Meram A, Patel S, Wei E, Ansaric J, Ghalia G, Kevil C, Shackelford RE.  Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Cavity Mucoepidermoid Carcinoma.  Case Rep Oncol. 2018;11:682–687.   doi: 10.1159/000493008
7. Jiang AS, Wu Z, Wei EX, Ni H, You B, Yang T, Jiang JG.  Plasma cell myeloma with dual expression of kappa and lambda light chains.  Int J Clin Exp Pathol 2018;11(9): 4718-4723
8. Dongsoo K, Chen J, Wei E, Ansari J, Meram A, Patel S, Ghali G, Kevil C, Shackelford RE.  Hydrogen Sulfide and Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Adenoid Cystic Carcinoma.  Case Rep Oncol. 2018 Aug 27;11(2):585-590. doi: 10.1159/000492464. eCollection 2018 May-Aug.
9. Egge S, Wei E, Clements E, Chandranesan ASJ.  Post-traumatic fatal disseminated Apophysomyces elegans infection. Med Mycol Case Rep. 2018 Sep 6;22:45-47. doi: 10.1016/j.mmcr.2018.08.002. eCollection 2018 Dec.
10. Chen S, Turbat-Herrera EA, Herrera GA, Chadha M, Shackelford RE, Wei EX.  Metastatic TFE3-overexpressing renal clear cell carcinoma with dense granules: a histological, immunohistochemical, and ultrastructural study.  Ultrastruct Pathol. 2018 Jul-Aug;42(4):369-375. doi: 10.1080/01913123.2018.1499686. Epub 2018 Jul 24.
11. Meram AT, Chen J, Patel S, Kim DD, Shirley B, Covello P, Coppola D, Wei EX, Ghali G, Kevil CG, Shackelford RE. Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae. Anticancer Res. 2018 Jul;38(7):3843-3852. doi: 10.21873/anticanres.12668.
12. Jiang JG, Xu Y, Wu Z, Ni H, Wei EX.  Acute myeloid leukemia developed in Ph- cells with MLL gene amplification in a patient with chronic myelogenous leukemia.  Leuk Lymphoma. 2018 Feb 23:1-3. doi: 10.1080/10428194.2018.1436174.
13. Wei EX, Silva R, Cotelingam JD, Shackelford RE.   Pediatric Pulmonary Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Case Report and Review of the Literature.  Case Rep Pathol.  2017;2017:8946807. doi: 10.1155/2017/8946807. Epub 2017 Oct 8.
14. Wei EX, Leventaki V, Choi JK, Raimondi SC, Azzato E, Shurtleff SA, Ong M, Veillon DM, Cotelingam JD, Shackelford RE.  γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies.  Case Rep Hematol.  Volume 2017 (2017), Article ID 5873015, 7 pages.  https://doi.org/10.1155/2017/5873015.
15. Shackelford RE, Ansari JM, Wei EX, Alexander JS, Cotelingam J.  Anaplastic lymphoma kinase rearrangements in non-small-cell lung cancer: novel applications in diagnostics and treatment.  Pharmacogenomics. 2017 Aug;18(12):1179-1192. doi: 10.2217/pgs-2017-0098. Epub 2017 Jul 26.
16. Shackelford RE, Abdulsattar J, Wei EX, Cotelingam J, Coppola D, Herrera GA.  Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma.  Anticancer Res. 2017 Jul;37(7):3423-3427.
17. Shackelford RE, Al Shaarani M, Ansari J, Wei E, Cotelingam J.  A Twenty-Four-Year-Old Woman with Left Flank Lipoma-Like Hibernoma.  Case Rep Oncol. 2017 May 9;10(2):438-441. doi: 10.1159/000475708. eCollection 2017 May-Aug.
18. Knowles KJ, Wei EX, Seth A, Bienvenu J, Morris J, Jordan P, and Boktor M.  Synthetic cannabinoid abuse and a rare alpha-1-antitrypsin mutant causing acute fulminant hepatitis. Case report and review of the literature.  Case Reports Hepatol. 2017 ; 2017:9627452. doi: 10.1155/2017/9627452. Epub 2017 Dec 3.
19. Barakat FH, Medeiros LJ, Wei EX, Konoplev S, Lin P, Jorgensen JL.  Residual Monotypic Plasma Cells in Patients with Waldenstrom Macroglobulinemia after Therapy. Am J Clin Pathol 2011 Mar; 35(3):365-73.
20. Muzzafar T, Wei EX, Lin P, Medeiros LJ, Jorgensen JL.  Flow cytometry immunophenotyping of anaplastic large cell lymphoma.  Arch Pathol Lab Med 2009 Jan;133(1):49-56.
21. Wei EX, Anga AA, Martin SS, Jackson JG, Nordberg ML, Herrera GA, Turbat-Herrera EA.  EGFR expression as an ancillary tool for diagnosing lung cancer in cytology specimens.  Mod Pathol 2007 Sept; 20(9):905-13. Epub 2007 Jul 20
22. Wei XE, Bao F, Veillon DM, Heldmann M, Cotelingam JD. Pathology case of the month.  A Mediastinal mass.  Castleman’s disease, hyaline-vascular type.  J La State Med Soc.  2006 Sept-Oct; 158(5):222-4, 226
23. Wei EX, Dancer YJ, Veillon DM, Linscott AJ, Dowden K, Fowler M, Cotelingam JD. Pathology case of the month.  Fever, Chills, and Weakness in a 61-Year-Old Man.  Mixed fungal infection: Blastomycosis (Blastomyces dermatitidis) and zygomycosis.  J La State Med Soc. 2005 Sept-Oct; 157(5):245-50.
24. Wei EX, Albores-Savvedra J, Fowler MR.  Plexiform neurofibroma of the uterine cervix.  Arch Pathol Lab Med.  2005 Jun;129(6):783-6.
25. Wei EX, Flamholz RB, Nordberg ML, Veillon DM, Behm W, Heldmann M, Cotelingam JD.  Pathology case of the month.  A mediastinal mass.  Malignant lymphoma, composite (nodular sclerosis Hodgkin lymphoma and diffuse large B-cell lymphoma).  J La State Med Soc. 2004 Nov-Dec; 156(6):294-7.
26. Wei XE, Veillon DM, Flamholz RB, Heldmann M, Grafton WD, Fowler MR, Cotelingam JD. Pathology case of the month. Tumor of the pineal region. Pineoblastoma, recurrent. J La State Med Soc. 2004 May-Jun;156(3):125-7, 129
27. Wei X, Sasaki M, Huang H, Dawson VL, Dawson TM. Steroidogenic factor 1 (SF-1), regulates neuronal nitric oxide synthase gene expression in pituitary gonadotropes. Mol Endocrinol 2002 Dec;16(12):2828-39
28. Jiang C, Wei X.  Current Status in Epilepsy Surgery Therapy.  Shanghai Medicine 1993 May;16(5): 299-304 
29. Jiang C, Wei X.  Recent Progress in Epilepsy Neurosurgery.  Chinese Journal of Stereotactic and Functional Neurosurgery 1993;6(1): 46-50

Selected Scientific Presentations

1. Ozluk E, Friday ER, Wei EX.  Advanced melanoma associates with high frequency TERT mutations. College of American Pathologists, Las Vegas, NV, 2020
2. Li Y, Friday ER, Wei EX.  The Molecular Genomic Profiling of Primary Lung Adenocarcinoma in Local Population.  College of American Pathologists, Las Vegas, NV, 2020
3. Xu H, Wei EX.  Frequent Mutations in p53, CDKN2A, PTEN Genes in Lung Squamous Cell Carcinoma: A Next Generation Sequencing Study.  American Society for Clinical Pathology, Austin, TX, 2020
4. Patil A, Tirupathi R, Dabrowski D, Ganti N, Vanga P, Otohinoyi D, Gundale A, Ghildyal A, Cotelingam J, Veillon D, Ong M, Dela Cruz N, Wei EX.  Establishing adrenocortical carcinoma specific prognostic genes signature.  American Society for Clinical Pathology, Austin, TX, 2020
5. Patil A, Tirupathi R, Dabrowski D, Ganti N, Vanga P, Otohinoyi D, Gundale A, Ghildyal A, Cotelingam J, Veillon D, Ong M, Dela Cruz N, Wei EX.  Genomic analysis identifies rare ALK positive cases in the TCGA database.  American Society for Clinical Pathology, Austin, TX, 2020
6. Mirza R, Aksionau A, Wei EX.  Next generation sequencing assay demonstrated frequent mutation in PI3K3CA, PI3R1 and p53 gene in clinically aggressive head neck squamous cell carcinoma.  USCAP, Los Angeles, CA 2020.  Modern Pathology 2020 March; 33(3 supplement 2):1214

Wei Xin, M.D., Ph.D.

Director, Anatomic Pathology
Professor
Department of Pathology
University of South Alabama
Adjunct Professor, Pathology
Case Western Reserve University

(251) 471-7795
wxin@health.southalabama.edu

Board Certification

American Board of Pathology: Anatomic and Clinical Pathology

Education

M.D.: Shanghai Medical University, China
Ph.D.: State University of New York at Buffalo
Residency: AP/CP pathology, The University of Michigan Hospitals, Ann Arbor
Fellowship: Surgical and GI Pathology, The University of Michigan Hospitals, Ann Arbor

Selected Publications

1. Min Cui, Qiang Wang , Alison Xin, Danian Che, Zhengbin Lu, Lan Zhou, Wei Xin. Vascular thrombosis and vasculitis in the gastrointestinal tract are associated with poor prognosis in patients with COVID-19. International Journal of Clinical and Experimental Pathology. 2021 Nov 15;14(11):1069-1079.

2. Muhammed Mustafa Alikhan, Emad Mansoor, Sagarika Satyavada, Katarina Greer, Wei Xin, Stanley Cohen, Gregory Cooper, Jeffry Katz. Infliximab-Induced Acute Liver Failure in a Patient With Crohn's Disease Requiring Orthotopic Liver Transplantation. ACG Case Reports Journal. 2021 May 14;8(5):e00586

3. Lei Wang Shuiliang Yu, Ernest Chan, Kai-Yuan Chen, Cui Liu, Danian Che, Amad Awadallah, Jay Myers, David Askew, Alex Huang, Ivan Maillard, Dan Huang, Wei Xin, and Lan Zhou. Notch-regulated Dendritic Cell Immunity Restrains Inflammation-associated Colorectal Carcinogenesis in Fx-/- Mice. Cancer Immunology Research. 2021 Jan 13, 9(3):348-361

4. Carlo De Salvo, Luca Pastorelli,  Christine P Petersen , Ludovica F Buttò , Kristine-Ann Buela, Sara Omenetti, Silviu A Locovei, Shuvra Ray, Hannah R Friedman, Jacob Duijser, Wei Xin, Abdullah Osme, Fabio Cominelli, Ganapati H Mahabeleshwar, Jason C Mills, James R Goldenring and Theresa T Pizarro. IL-33 triggers early eosinophil-dependent events leading to metaplasia in a chronic model of gastritis-prone mice. Gastroenterology. Jan 2021; 160(1):302-316.e7

5. Daniele Corridoni, Agne Antanaviciute, Tarun Gupta, David Fawkner-Corbett, Marta Jagielowicz , Kaushal Parikh, Emmanouela Repapi, Stephen Taylor, Dai Ishikawa, Ryo Hatano, Wei Xin,  Hubert Slawinski, Rory Bowden, Giorgio Napolitani, Chikao Morimoto, Hashem Koohy, Anna Aulicino, Taketo Yamada and Alison Simmons. Single-cell Atlas of Colonic CD8+ T-cells in Ulcerative Colitis. Nature medicine. 2020 Sep;26(9):1480-1490.

6. Wei Chen, Amad Awadallah, Lan Zhou, Zhenghong Lee and Wei Xin. Peritumoral/vascular expression of PSMA as a diagnostic marker in hepatic lesions. Diagnostic Pathology. 2020 Jul 23;15(1):92. doi: 10.1186/s13000-020-00982-4

7. Min Cui, Zhenjian Cai, Amad Awadallah and Wei Xin.  Uniform and Robust Nuclear Expression of Hes-1 in Neuroendocrine Neoplasms. International Journal of Surgical Pathology. 2019 Dec; 7(8): 44-851 

8. Yiwei Wang, Dan Huang, Kai-Yuan Chen, Min Cui, Weihuan Wang, Xiaoran Huang, Amad Awadellah, Qing Li,  Ann Friedman, Luca Di Martino,  Fabio Cominelli,  Alex Miron, Ricky Chan, James Fox, Yan Xu, Xiling Shen,  Mathew Kalady, Sanford Markowitz, Ivan Maillard, John Lowe, Wei Xin and Lan Zhou. Fucosylation-deficiency Leads to Serrated Lesions and Colon Adenocarcinoma. Gastroenterology. 2017 Jan;152(1):193-205

9. Luca Di Martino, Maneesh Dave, Paola Menghini, Wei Xin, Kristen Arseneau, Theresa Pizarro and Fabio Cominelli. Protective role for TWEAK/Fn14 in regulating acute intestinal inflammation and colitis-associated tumorigenesis. Cancer Research. 2016 Nov 15;76(22):6533-6542

10. Yiwei Wang, Shuiliang Yu, Dan Huang, Min Cui, Huankai Hu, Barbara Osborn, Chaoyang Li, Wei Xin*, Lan Zhou*. Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1. American Journal of Pathology, 2016 Nov;186(11):2945-2956. *shared senior authorship

11. Weihuan Wang, Greg Zimmerman, Xiaoran Huang, Shuiliang Yu, Jay Myers, Yiwei Wang, Moreton S, Nthale J, Amad Awadallah, Rose Beck, Wei Xin, David Wald D, Alex Huang, Lan Zhou. Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. Cancer Research. 2016 Mar 15; 76(6):1641-52.

12. Min Cui, Amad Awadallah, Wendy Liu, Lan Zhou and Wei Xin. Loss of Hes1 Differentiates Sessile Serrated Adenoma/polyp from Hyperplastic polyp. American Journal of Surgical Pathology. 2016 Jan;40(1):113-9

13. Alex Rodriguez-Palacios, Tomohiro Kodani, Lindsey Kaydo, Davide Pietropaoli, Daniele Corridoni, Scott Howell, Jeffry Katz, Wei Xin, Theresa T. Pizarro, Fabio Cominelli.  Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes. Nature Communication 2015 Jul 8. 6:7577

14. Wenbin Xiao, Hong Hong, Shuiliang Yu, Lan Zhou and Wei Xin. CRABP-II is a highly sensitive and specific diagnostic molecular marker for pancreatic ductal adenocarcinoma in distinguishing from benign pancreatic conditions. Human Pathology. 2014 June 45(6):1177-83

15. Kianoush Ansari-Gilani, Trevor Jenkins, Luis Landeras, Wei Xin, Prabhakar Rajiah Multimodality imaging of an unusual case of an obstructive intracaval mass by an aberrant liver. Circulation 2014 Feb 4;129(5):e310-2

16. Wenbin Xiao, Hong Hong, Amad Awadallah, Lan Zhou and Wei Xin. Utilization of CDX2 Expression in Diagnosing Pancreatic Ductal Adenocarcinoma and Predicting Prognosis. PLOS One, 2014 Jan 29;9(1):e86853

17. Daniele Corridoni, Tomohiro Kodani, Alexander Rodriguez-Palacios, Theresa T. Pizarro, Wei Xin, Kourtney P Nickerson, Christine McDonald, Klaus F. Ley, Derek W. Abbott, Fabio Cominelli. A dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2013 Oct 15;110(42):16999-7004.

18. Huankai Hu, Lan Zhou, Amad Awadallah and Wei Xin. Significance of Notch1 Signaling Pathway in Human Pancreatic Development and Carcinogenesis. Applied Immunohistochemistry & Molecular Morphology. 2013 May;21(3):242-7.

19. Dai Ishikawa, Okazawa A, Daniele Corridoni, Li-guo Jia, Xiao-ming Wang, Mitchelle Guanzon, Wei Xin,  Kristen O. Arseneau, Theresa T. Pizarro, Fabio Cominelli.  Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease. Mucosal Immunology. 2013 Mar;6(2):267-75.

20. Wenbin Xiao,  Amad Awadallah, Wei Xin. Loss of ARID1A/BAF250a Expression in Ovarian Endometriosis and Clear Cell Carcinoma.  International Journal of Clinical and Experimental Pathology. 2012;5(7):642-650. 

21. David Yao, Yuanshuai Huang, Xiaoran Huang, Weiping Wang, Quanjian Yan, Lebin Wei, Wei Xin, Stanley P Gerson, John B Lowe, Lan Zhou. Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. Blood. 2011 May; 117(21):5652-62. 

22. Man-sun Sy, Chaoyang Li, Shuiliang Yu and Wei Xin. The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers. Biomarkers in Medicine. 2010 Jun;4(3):453-64

23. Chaoyang Li, Shuiliang Yu, Jinghua Xu, Amber A Petrolla, Fumihiko Nakmura, Shaoman Yin, Neena Singh, Thomas Stossel, Alan Tartakoff, Derek Abbot, Wei Xin and Man-sun Sy. Binding of Prion Pro-protein to Filamin A Disrupts Cytoskeletal organization and Signaling that Provides Growth Advantage to Human Pancreatic Ductal Carcinomas. Journal of Clinical Investigation, 2009 Aug; 119(9):2725-2736

24. Amber A Petrolla, Jeffrey A Katz and Wei Xin. The Clinical Significance of Focal Enhanced Gastritis in Adults with Isolated Terminal Ileitis, Journal of Gastroenterology. 2008 Jul; 43(7):524-530. 

25. Amber A Petrolla and Wei Xin. Hepatic Angiomyolipoma. Archives of Pathology and Laboratory Medicine. 2008 Oct; 132(10):1679-1682. 

26. Wei Xin and Joel K. Greenson. The Clinical Significance of Focally Enhanced Gastritis. American Journal of Surgical Pathology. 2004 Oct; 28(10):1347-1351.

27. Wei Xin, Kim J. Yun, Francesca Ricci, Marianna Zahurak, Wanglong Qiu, Gloria H. Su, Charles J. Yeo, Scott E. Kern, Ralph H. Hruban and Christine A. Iacobuzio-Donahue. Evaluation of MKK4 Expression in Pancreatic Cancer using Tissue Microarray Technology: Relationship to Genetic status, Metastasis and Prognosis. Clinical Cancer Research, 2004 Dec; 10: 8516-8520.

28. Yasunori Ogura, Sanja Lala, Wei Xin, Elisabeth Smith, Theresa A. Dowds, Felicia F. Chen, Ellen Zimmermann, Maria Tretiakova, Judy Cho, John Hart, Joel Greenson, Satish Keshav and Gabriel Nuñez. Expression of NOD2 in Panneth Cells: A Possible Link to Crohn's Ileitis. Gut. 2003 Nov; 52:1591-1597.

29. Wei Xin, Pamela I Brown and Joel K Greenson. The Clinical Significance of Focal Active Colitis in Pediatric Patients. The American Journal of Surgical Pathology. 2003 Aug; 27(8): 1134-1138.

30. Wei Xin, Stephen Raab and Claire W Michael. Low Grade Urothelial Carcinoma: Reappraisal of the Cytologic Criteria on ThinPrep®. Diagnostic Cytopathology. 2003 Sep; 29(3):125-129.

31. Wei Xin, Saravana M. Dhanasekaran, Collette Ingold, Kenneth J. Pienta, Arul M. Chinnaiyan and Mark A. Rubin. Dysregulation of Selected Annexin Family Proteins is Associated with Prostate Cancer Progression. The American Journal of Pathology. 2003 Jan; 162(1): 255-61.

32. Wei Xin, Mark A Rubin and Paul E. McKeever. The Differential Expression Patterns of Cytokeratins 8 and 20 Distinguish Craniopharyngioma and Rathke Cleft Cyst. Archives of Pathology and Laboratory Medicine. 2002 Oct; 126(10): 1174-1178.

33. Wei Xin and Jui H. Wang. Treatment of Duck hepatitis B Virus by Poly-DNP-oligonucleotides” Antisense and Nucleic acid Drug Development. 1998 Dec, 8(6), 459-468